Treatment of brachial plexus injury with modified contralateral C<sub>7</sub>transfer

Zou, Yun-wen; Wang, Zhijie; Yu, Hong

doi:10.1111/j.1757-7861.2009.00057.x

Cited by 14 publications

(8 citation statements)

References 6 publications

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“…7, 10–34 The studies were divided into whole CC7 (n=16) and partial CC7 (n=11). Three studies reported two CC7 types, 9, 12, 25 and the CC7 type was not available in 3 studies 10, 13, 33 that were only included in overall study (Table 2). …”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of Outcomes of Contralateral C7 Transfer for the Treatment of Traumatic Brachial Plexus Injury

Yang

Chang

Chung

2015

Plastic and Reconstructive Surgery

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Background Although contralateral C7 (CC7) transfer has been widely used for treating traumatic brachial plexus injury, the procedure safety is questionable. We performed a systematic review to investigate the donor-site morbidity including sensory abnormality and motor deficit to guide clinical decision-making. Methods A systematic review on CC7 transfer for traumatic brachial plexus injury was performed for the original articles in PubMed and EMBASE databases. Patient demographic data and donor-site morbidity of CC7 transfer including incidence, recovery rate and time were extracted from the included studies. The sensory abnormality areas and muscles involved in motor weakness were also summarized. Results A total 904 patients from 27 studies were reviewed. Overall, 74% of patients (668/897) experienced sensory abnormalities, and 98% of patients (618/633) recovered to normal; the mean recovery time was 3 months. For motor function, 20% of patients (118/592) had motor deficit after CC7 transfer and 91% (107/117) regained normal motor functions; mean recovery time was 6 months. Sensory abnormality mainly happened in the median innervated area of the hand, whereas motor deficit most often involved radial nerve innerved muscles. There were 2% of patients (19/904) with long-term morbidity of donor site in the studies. Conclusions The incidence of donor-site morbidity after CC7 transfer was relatively high, and severe and long-term defects occurred occasionally. CC7 transfer should be indicated only when other donor nerves are not available, and with a comprehensive knowledge of the potential risks. Level of evidence Level III

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Section: Resultsmentioning

confidence: 99%

“… § N, number; y, year; mo, month; † Three studies 9, 12, 25 reported two CC7 types, and the CC7 types were not available in 3 studies 10, 13, 33 , so there were 27 studies. …”

Section: Figurementioning

confidence: 99%

A Systematic Review of Outcomes of Contralateral C7 Transfer for the Treatment of Traumatic Brachial Plexus Injury

Yang

Chang

Chung

2015

Plastic and Reconstructive Surgery

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“…It's effective in restoring partial sensation of hand,wrist and finger flexion without permanent sensory and motor damages to the healthy side [3,9]. Because the number of myelinated nerve fibers of cC7 root is much more than that of any recipient nerve including radial nerve, median nerve or musculocutaneous nerve, some scholars have tried to repair two recipient nerves simultaneously by cC7 transfer [7,24,25,27]. They have found that both of the two recipient nerves have achieved recoveries.…”

Section: Introductionmentioning

confidence: 99%

Contralateral C7 transfer to axillary and median nerves in rats with total brachial plexus avulsion

Liu

Xiao

Zhuang

et al. 2020

BMC Musculoskelet Disord

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Background: Contralateral cervical 7 nerve (cC7) was used to repair two recipient nerves simultaneously for patients with total brachial plexus avulsion (TBPA). Objective: To evaluate the effect of cC7 transfer to axillary and median nerves in rats with TBPA.Methods: Eighty S-D rats were divided into 4 groups randomly on average. Group A: cC7-median nerve, Group B: cC7axillary nerve, Group C: cC7-median and axillary nerves, Group D: TBPA without repair. The evaluation tools included behavioral tests, electromyogram (EMG), measurement of cross-sectional area of muscle fiber, nerve fiber count and gene expression assay. Results: The effective rates of EMG were 90 and 70% in Flexor Carpi Radialis (FCR) in Group A and C, while 70 and 60% in deltoid (DEL) in Group B and C, respectively. In behavioral test, the differences of effective rates between groups were not significant. The mean cross-sectional area of FCR in Group A or C was significantly larger than that in Group D. Either the number of median or axillary nerve fibers in Group A, B or C was statistically more than that in Group D. No matter for FCR or DEL, there were no significant differences in the ratios of relative expression of Muscle Atrophy Fbox(MAFBOX)and Muscle RING Finger 1(MURF1)among these groups. Conclusion: Compared with cC7 transfer to median nerve, cC7 transfer to both median and axillary nerves did not affect median nerve recovery. The deltoid muscle also could be restored. The recovery proportion of axillary nerve was less than that of median nerve.

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“…It's effective in restoring partial sensation of hand ,wrist and finger flexion without permanent sensory and motor damages to the healthy side. 3,9 Because the number of myelinated nerve fibers of cC7 root is much more than that of any recipient nerve including radial nerve, median nerve or musculocutaneous nerve, some scholars have tried to repair two recipient nerves simultaneously by cC7 transfer 7,24,25,27 . They have found that both of the two recipient nerves have achieved recoveries.…”

Section: Introductionmentioning

confidence: 99%

Contralateral C7 Transfer to Axillary and Median Nerves in Rats with Total Brachial Plexus Avulsion

Liu

Xiao

Zhuang

et al. 2020

Preprint

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Background: Contralateral cervical 7 nerve (cC7) was used to repair two recipient nerves simultaneously for patients with total brachial plexus avulsion (TBPA). Objective: To evaluate the effect of cC7 transfer to axillary and median nerves in rats with TBPA. Methods: Eighty S-D rats were divided into 4 groups randomly on average. Group A: cC7 － median nerve, Group B: cC7 － axillary nerve, Group C: cC7 － median and axillary nerves, Group D: TBPA without repair. The evaluation tools included behavioral tests, electromyogram (EMG), measurement of cross-sectional area of muscle fiber, nerve fiber count and gene expression assay. Results: The effective rates of EMG were 90% and 70% in Flexor Carpi Radialis (FCR) in Group A and C, while 70% and 60% in deltoid (DEL) in Group B and C, respectively. In behavioral test, the differences of effective rates between groups were not significant. The mean cross-sectional area of FCR in Group A or C was significantly larger than that in Group D. Either the number of median or axillary nerve fibers in Group A, B or C was statistically more than that in Group D. No matter for FCR or DEL, there were no significant differences in the ratios of relative expression of Muscle Atrophy F-box （ MAFBOX ） and Muscle RING Finger 1 （ MURF1 ） among these groups. Conclusion: Compared with cC7 transfer to median nerve, cC7 transfer to both median and axillary nerves did not affect median nerve recovery. The deltoid muscle also could be restored. The recovery proportion of axillary nerve was less than that of median nerve.

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Treatment of brachial plexus injury with modified contralateral C₇transfer

Abstract: The method of partial C(7) root transfer results in equally good motor function as does transfer of the whole root, while occurrence of motor and sensory damage is less than that which occurs with transfer of the whole root.

Cited by 14 publications

References 6 publications

A Systematic Review of Outcomes of Contralateral C7 Transfer for the Treatment of Traumatic Brachial Plexus Injury

A Systematic Review of Outcomes of Contralateral C7 Transfer for the Treatment of Traumatic Brachial Plexus Injury

Contralateral C7 transfer to axillary and median nerves in rats with total brachial plexus avulsion

Contralateral C7 Transfer to Axillary and Median Nerves in Rats with Total Brachial Plexus Avulsion

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Treatment of brachial plexus injury with modified contralateral C7transfer

Abstract: The method of partial C(7) root transfer results in equally good motor function as does transfer of the whole root, while occurrence of motor and sensory damage is less than that which occurs with transfer of the whole root.

Cited by 14 publications

References 6 publications

A Systematic Review of Outcomes of Contralateral C7 Transfer for the Treatment of Traumatic Brachial Plexus Injury

A Systematic Review of Outcomes of Contralateral C7 Transfer for the Treatment of Traumatic Brachial Plexus Injury

Contralateral C7 transfer to axillary and median nerves in rats with total brachial plexus avulsion

Contralateral C7 Transfer to Axillary and Median Nerves in Rats with Total Brachial Plexus Avulsion

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Treatment of brachial plexus injury with modified contralateral C₇transfer