Treatment of breast cancer among elderly women with segmental mastectomy or segmental mastectomy plus plus postoperative radiotherapy

Kantorowitz, David A.; Poulter, Colin; Sischy, Ben; Paterson, Eileen; Sobel, Sidney H.; Rubin, Philip; Dvoretsky, Philip A.; Mishalak, William; Doane, K.

doi:10.1016/s0360-3016(98)90003-7

Cited by 92 publications

(30 citation statements)

References 16 publications

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“…Studies are conflicting if similar risks of local recurrence in the elderly without radiation are present. A small U.S. case series found that 38 percent of women age 70 to 79 treated with BCS alone had a local recurrence at median follow-up of 51 months [24]. However, a recent Italian randomized study that specifically looked at the risk in older women, age > 55, with small (< 25 mm) tumors found that only 4 percent of women who did not receive radiation had local recurrences after four years [25].…”

Section: Discussionmentioning

confidence: 99%

Variation in staging and treatment of local and regional breast cancer in the elderly

Hillner

Penberthy

Desch

et al. 1996

Breast Cancer Res Tr

107

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Younger age was most consistently associated with staging and the use of chemotherapy in this cohort of elderly breast cancer patients. Based on the reported initial treatment plan, hormonal therapy was infrequently used and information from axillary lymph node assessment was used to stratify treatment. Although the low use of adjuvant hormonal therapy in elderly women may compromise survival, neither comorbid nor socioeconomic factors as measured in this study explained this practice pattern.

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Section: Discussionmentioning

confidence: 99%

Variation in staging and treatment of local and regional breast cancer in the elderly

Hillner

Penberthy

Desch

et al. 1996

Breast Cancer Res Tr

107

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“…12 Concerns regarding serious side effects of adjuvant radiotherapy in elderly patients were negated by a retrospective analysis which revealed that elderly patients seldom had major complications following adjuvant radiotherapy after breast conservation surgery. 58 Studies have shown that ER status and margins of excision were related to development of local recurrence in patients who did not receive adjuvant radiotherapy following breast conservation surgery. 59 The local recurrence rate in patients who did not receive radiotherapy was lower in those with ER positive tumour and adequate excision margins more than 5 mm.…”

Section: Adjuvant Treatmentmentioning

confidence: 99%

Management of early breast cancer in the elderly

Rao

Garimella

Hwang

et al. 2007

Intl Journal of Cancer

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Breast cancer is the most common malignancy in women with an age related increase in incidence ranging from 1 in 50 at age 50 to 1 in 10 at age 80. This is particularly significant in view of the changing demographics in the western population, characterised by an aging population and increased life expectancy. However in spite of favourable prognostic factors and less aggressive biological behaviour, elderly breast cancer patients receive less aggressive treatment when compared with their younger counterparts. Appropriate treatment should be offered depending on physiological reserve and comorbidities. Primary endocrine treatment has been shown to be associated with significant morbidity in terms of disease progression. Prompt surgery and adjuvant treatment can decrease relapse and improve survival. Radiation therapy is shown to decrease local relapse and chemotherapy may have a role in a select group of patients with adverse prognostic factors. With incidence of breast cancer bound to increase in the elderly population, it is essential to establish optimum therapy in this cohort of patients as studies reveal good outcome from standard treatment. ' 2007 Wiley-Liss, Inc.Key words: elderly breast cancer; primary endocrine treatment; conservative surgery; radiotherapy; chemotherapy Breast cancer is the most common malignancy in women and the incidence increases with age: 1 in 50 at age 50, 1 in 14 by age 70 and 1 in 9 by age 85. With changing demographics in the western hemisphere characterized by an aging population and increased life expectancy, the total incidence of breast cancer can be expected to increase with peak incidence occurring between 70 and 84 years.1 In the United States, women over the age of 65 have become a prominent cohort in the breast cancer population, with approximately 50% of all new breast cancers occurring in women aged 65 years and older and 25% occur after the age of 75 years.

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“…In a non-randomised study, Kantorowitz et al, reported that only 40% of patients aged over 60 years were referred for post-operative irradiation after wide local excision, (Kantorowitz et al, 1988). Relapse of cancer within the breast occurred in 40% of those who were not irradiated, compared with only 6% of those given post-operative radiotherapy.…”

Section: Radiotherapymentioning

confidence: 99%

Treatment of cancer in the elderly

Fentiman¹

1991

Br J Cancer

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Within the European community more than a million individuals develop cancer every year (Moller Jensen et al., 1990). Of these cases, over 50% will be aged over 70 years and this proportion will gradually increase as a result of longevity since age is a major risk determinant for malignancy. Despite the frequency of cancer in the elderly, treatment has often been given on an ad hoc basis and very rarely have structured management schemes been tested in prospective randomised trials. Undertreatment of cancer has been rife, irrespective of tumour site and the discipline of the clinician looking after the patient.

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Treatment of breast cancer among elderly women with segmental mastectomy or segmental mastectomy plus plus postoperative radiotherapy

Cited by 92 publications

References 16 publications

Variation in staging and treatment of local and regional breast cancer in the elderly

Variation in staging and treatment of local and regional breast cancer in the elderly

Management of early breast cancer in the elderly

Treatment of cancer in the elderly

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