Demodicosis is a common canine ectoparasitosis. Recognising the clinical presentation, identifying the parasite and choosing the most appropriate therapy are essential for the successful management of a patient. There are various acaricides and the recent advent of safer and more effective drugs has made the treatment of affected animals much easier than previously. This article aims to help veterinary practitioners choose the safest and most efficient therapy for canine demodicosis and focuses on the treatment options available in the UK.