Treatment of Chemotherapy-Induced Peripheral Neuropathy in Integrative Oncology: A Survey of Acupuncture and Oriental Medicine Practitioners

Lu, Zhaoxue; Moody, Jennifer P.; Marx, Benjamin L.; Hammerstrom, Tracy

doi:10.1089/acm.2017.0052

Cited by 21 publications

(19 citation statements)

References 33 publications

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“…Acupuncture has been used for the treatment of CIPN as one of adjunctive management in integrative cancer care [ 15 ]. Nevertheless, there is no consensus on the choice of acupuncture point and the protocol of acupuncture treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, there is no consensus on the choice of acupuncture point and the protocol of acupuncture treatment. In a survey of acupuncture and oriental medicine practitioners [ 15 ], needle retention times and treatment frequency varied among the practitioners. In other previous studies, duration of intervention varied from 30 days to 28 weeks [ 11 – 13 , 18 , 27 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, acupuncture is increasingly being integrated into adjuvant treatment of cancer patients [ 14 ], but the protocol of acupuncture is not standardized and the treatment outcomes are inconsistent [ 15 ]. To utilize acupuncture for the treatment of CIPN in breast cancer based on evidence-based medicine, more data on clinical trials are necessary.…”

Section: Introductionmentioning

confidence: 99%

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Acupuncture for the Treatment of Taxane‐Induced Peripheral Neuropathy in Breast Cancer Patients: A Pilot Trial

Jeong

Kwak

Seo³

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Objectives Some chemotherapy drugs can damage the nerves and cause peripheral neuropathy which is accompanied by severe neuropathic pain or gait impairment. The purpose of this study was to assess the feasibility and the safety of acupuncture for the treatment of peripheral neuropathy following chemotherapy in Korean breast cancer patients. Design This study was a prospective single-arm observational study using before and after measurements in breast cancer patients presenting with taxane-induced peripheral neuropathy. Settings/Location This study was performed at East-West Medical Center at Daegu Catholic University Hospital, Daegu, South Korea. Interventions Acupuncture was administered 3 times a week for 4 consecutive weeks, for 25 ± 5 minutes at each session. Outcome Measures The primary outcome measure was severity of CIPN using the Neuropathic Pain Symptom Inventory (NPSI) assessed by a self-administered questionnaire and Nerve Conduction Study (NCS) of extremities. The secondary outcome measure was quality of life (QoL) assessed by a self-administered questionnaire using the 36-Item Short From Health Survey (SF-36). Results Acupuncture significantly reduced the severity of CIPN assessed by NPSI score. Four weeks after the last treatment, the symptoms were not aggravated. According to NCS, 42.9% of participants showed improvement of sensory neuropathy. At the end of the treatment, SF-36 scores were significantly increased for variables including physical functioning, role limitations due to physical health problems, social functioning, and general health perceptions compared to those of baseline measurement. Conclusions Acupuncture improved symptoms of CIPN and QoL in Korean women suffering from peripheral neuropathy after chemotherapy using taxane for breast cancer. The effects of acupuncture lasted for at least 1 month after the treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acupuncture for the Treatment of Taxane‐Induced Peripheral Neuropathy in Breast Cancer Patients: A Pilot Trial

Jeong

Kwak

Seo³

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…CHM has played a positive role in cancer therapy, especially as an adjuvant treatment, which is often used in China to enhance the antitumor effects of Western medicines and protect cancer patients from suffering from adverse treatment effects. These protections include preventing complications due to surgery, reducing toxic effects associated with cancer therapies, alleviating multiple clinical symptoms attributed to cancer, strengthening the body's immunity to prevent recurrence and metastasis, boosting the immune system, prolonging the survival time of postoperation and advancedstage cancer patients, and improving their quality of life [21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Meta-Analysis of Xihuang Pill Efficacy When Combined with Chemotherapy for Treatment of Breast Cancer

Mao

Feng

Huang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Objective. To systematically evaluate the efficacy of Xihuang pill (XHP) in breast cancer patients receiving chemotherapy. Methods. Three English and four Chinese databases were searched. Literature was screened using EndNote X7 and data were analyzed by Review Manager. Results. This review included 13 randomized clinical studies of 1272 patients. The results showed that XHP increased the tumor response [risk ratio (RR) = 2.91; 95% confidence interval (CI): 1.98-4.26] and improved Karnofsky performance score (KPS) for breast cancer patients receiving chemotherapy [RR = 4.96; 95% CI = 2.07-11.86]. In addition, XHP treatment significantly reduced chemotherapy-induced adverse events, including nausea and vomiting [RR = 0.50; 95% CI = 0.33-0.74], WBC reduction [RR = 0.71; 95% CI = 0.47-1.06], platelet reduction [RR = 0.53; 95% CI = 0.19-1.44], hemoglobin reduction [RR = 0.31; 95% CI = 0.19-0.52], and hepatic function damage [RR = 0.63; 95% CI = 0.35-1.11]. Conclusion. XHP combined with chemotherapy in comparison with chemotherapy alone could significantly enhance the tumor response, improve KPS, and alleviate toxicity induced by chemotherapy in breast cancer patients.

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“…session per week over 12 consecutive weeks. The most frequently used acupuncture points in CIPN are ba feng (EX-LE10), ba xie (EX-UE9), tai chung (LV3), he gu (LI4)[14]. Among them, the traditional effects of the points in hands and feet are regulating Qi and blood circulation and treating localized problems.…”

mentioning

confidence: 99%

The efficacy and safety of electro-acupuncture for alleviating chemotherapy-induced peripheral neuropathy in patients with coloreactal cancer: study protocol for a single-blinded, randomized sham-controlled trial

Chan

Lui

et al. 2020

Trials

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Background: Colorectal cancer is the most common cancer in Hong Kong. Oxaliplatin-based chemotherapy is a major first-line conventional therapy for advanced and metastatic colorectal cancer. However, oxaliplatin causes chemotherapy-induced peripheral neuropathy (CIPN). Acupuncture has long been used to alleviate limb numbness in Chinese medicine. This study aims to examine the efficacy and safety of acupuncture for alleviating CIPN in patients with colorectal cancer in Hong Kong. Methods/design: This is a single-blinded, randomized, sham-controlled efficacy trial. Eighty-four eligible patients, who are Hong Kong Chinese, aged ≥ 18 years, diagnosed with colorectal cancer and undergoing oxaliplatin-based chemotherapy, will be randomized in a ratio of 1:1 to the electro-acupuncture group or the sham-controlled group. During a 12-week treatment period, patients in the electro-acupuncture group will undergo electro-acupuncture once a week from the first cycle of chemotherapy, while patients in the control group will receive sham acupuncture, and the patients in both groups will be followed up for 12 weeks. The primary outcome measure is the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOC-Ntx) questionnaire. The secondary outcome measures include numerical rating scale (NRS) for numbness/pain, vibration and light touch sense test, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) and Constitution of Chinese Medicine Questionnaire (CCMQ). Discussion: The study will compare electro-acupuncture with sham acupuncture to explore the feasibility for electro-acupuncture in improving symptoms caused by chemotherapy-induced peripheral neuropathy.

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Treatment of Chemotherapy-Induced Peripheral Neuropathy in Integrative Oncology: A Survey of Acupuncture and Oriental Medicine Practitioners

Cited by 21 publications

References 33 publications

Acupuncture for the Treatment of Taxane‐Induced Peripheral Neuropathy in Breast Cancer Patients: A Pilot Trial

Acupuncture for the Treatment of Taxane‐Induced Peripheral Neuropathy in Breast Cancer Patients: A Pilot Trial

Meta-Analysis of Xihuang Pill Efficacy When Combined with Chemotherapy for Treatment of Breast Cancer

The efficacy and safety of electro-acupuncture for alleviating chemotherapy-induced peripheral neuropathy in patients with coloreactal cancer: study protocol for a single-blinded, randomized sham-controlled trial

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