Treatment of Chronic Stomatitis of Cats by Local Paramunization with PIND‐ORF

Abstract

33 cats, suffering from chronic stomatitis, were treated with orally given paramunity inducer I'IND-ORF (local paramunization). As a control 39 cats in the same practice were treated with other conventional methods.The reconvalescence rate (healing without rezidives) of experimental animals was 42 YO. From control animals only 13 YO reached this status. Oral paramunization with PIND-ORF is recommended as an alternative treatment for hitherto existing therapeutic measures against chronic stomatitis.

Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature

“…The most common reasons for study exclusion were manuscripts focusing on species other than cats (i.e., humans) as well as articles discussing treatment of other feline diseases, such as feline immunodeficiency virus, and mentioning stomatitis as a clinical sign or sequela. After assessing the included 16 studies, 4 were assigned an EDG of I ( 12 , 28 , 36 , 37 ), 3 were assigned an EDG of II ( 10 , 11 , 38 ), 3 were assigned an EDG of III ( 39 – 41 ), 1 was assigned an EDG of IV ( 42 ), and 5 were assigned an EDG of V ( 43 – 47 ). Seven studies (43.8%) were prospective clinical trials, three studies were retrospective (18.7%), and six studies were case reports presenting the outcome of one or two cats (37.5%).…”

“…Seven studies (43.8%) were prospective clinical trials, three studies were retrospective (18.7%), and six studies were case reports presenting the outcome of one or two cats (37.5%). There were 10 forms of medical management evaluated in these studies: Zincreo germicidal astringent obtundent ( 43 ), local paramunization with PIND-ORF (parapoxvirus ovis) ( 38 ), thalidomide ( 44 ), lactoferrin ( 37 , 44 ), cyclosporine ( 12 , 40 ), recombinant feline interferon omega ( 28 , 42 , 46 ), prednisolone ( 28 ), diet ( 36 ), piroxicam ( 37 ), and autologous mesenchymal stem cells ( 10 ). There were six studies that focused on surgical management, discussing efficacy of dental extractions ( 11 , 36 , 39 , 41 , 45 ) and use of carbon dioxide laser treatment as an adjunct to dental extractions ( 47 ).…”

Einsatz von Paramunitätsinducern in der Kleintiermedizin

“…Unter Paramunisierung versteht man die durch Paramunitätsinducer induzierten Reaktionen, die das unspezifische Immunsystem stärken, Abwehrschwächen beseitigen und einem Individuum einen schnellen, unspezifischen Schutz gegenüber einer Vielzahl ganz unterschiedlicher Noxen und Erreger vermitteln (22). Die durch Paramunisierung vermittelte Paramunität imitiert die natürlichen Reaktionen des unspezifischen Immunsystems.…”

“…Sie finden seit Jahrzehnten bei unterschiedlichen Spezies und verschiedenen Indikationen Anwendung. Prophylaktisch werden (22,24).…”

“…Die Rekonvaleszenzrate der Katzen aus einer Kontrollgruppe, die konventionell behandelt wurde, lag hingegen nur bei 13%. In dieser Studie erfolgte die Applikation von PIND-ORF jedoch nicht, wie üblich, subkutan, sondern oral (26).…”