Treatment of Chronic Wounds With Bone Marrow–Derived Cells

Badiavas, Evangelos V.; Falanga, Vincent

doi:10.1001/archderm.139.4.510

Cited by 397 publications

(283 citation statements)

References 27 publications

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“…Similarly, as pluripotential stem cells are capable of differentiating into a variety of cell types including fibroblasts and keratinocytes, stem cell therapy may be efficacious in chronic wounds. Preliminary data have suggested that autologous bone marrow cells applied to chronic wounds might accelerate healing [100].…”

Section: Wound Healing and The Importance Of Offloadingmentioning

confidence: 99%

The diabetic foot: from art to science. The 18th Camillo Golgi lecture

2004

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Diabetic foot ulceration represents a major medical, social and economic problem all over the world. While more than 5% of diabetic patients have a history of foot ulceration, the cumulative lifetime incidence may be as high as 15%. Ethnic differences exist in both ulcer and amputation incidences, with both being less common in patients of Indian subcontinent origin living in the UK. Foot ulceration results from the interaction of several contributory factors, the most important of which is neuropathy. With respect to the management of acute Charcot neuroarthropathy in diabetes, recent studies suggest that bisphosphonates reduce disease activity as judged not only by differences in skin temperature, but also by assessing markers of bone turnover. The use of the total-contact cast is demonstrated in the treatment of acute Charcot feet and of plantar neuropathic ulcers. Histological evidence suggests that pressure relief results in chronic foot ulcers changing their morphological appearance by displaying some features of an acute wound. Thus, repetitive stresses on the insensate foot appear to play a major role in maintaining ulcer chronicity. It is hoped that increasing research activity in foot disease will ultimately result in fewer ulcers and less amputation in diabetes.

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Section: Wound Healing and The Importance Of Offloadingmentioning

confidence: 99%

The diabetic foot: from art to science. The 18th Camillo Golgi lecture

2004

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“…BM can also generate epithelial cells, i.e., keratinocytes, in the epithelia, although the precise derivations and mechanisms to raise BM-derived keratinocytes are not fully known (3,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Human/mouse studies involving transplantation of sex-mismatched or genetically tagged BM cells have shown that keratin-positive bone marrow-derived cells can be found in skin epidermis, hair follicles, and sebaceous glands (6,8,9,11,12,14,16), sites that harbor skin stem cell niches (17). Moreover, in humans who have undergone BM transplantation (BMT), donor cells that have differentiated into keratinocytes can be detected in the epidermis for at least 3 y (8).…”

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confidence: 99%

PDGFRα-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia

Tamai

Yamazaki

Chino

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

220

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The role of bone marrow cells in repairing ectodermal tissue, such as skin epidermis, is not clear. To explore this process further, this study examined a particular form of cutaneous repair, skin grafting. Grafting of full thickness wild-type mouse skin onto mice that had received a green fluorescent protein-bone marrow transplant after whole body irradiation led to an abundance of bone marrow-derived epithelial cells in follicular and interfollicular epidermis that persisted for at least 5 mo. The source of the epithelial progenitors was the nonhematopoietic, platelet-derived growth factor receptor α-positive (Lin − /PDGFRα + ) bone marrow cell population. Skin grafts release high mobility group box 1 (HMGB1) in vitro and in vivo, which can mobilize the Lin − /PDGFRα + cells from bone marrow to target the engrafted skin. These data provide unique insight into how skin grafts facilitate tissue repair and identify strategies germane to regenerative medicine for skin and, perhaps, other ectodermal defects or diseases.

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“…1 and 2) and applied ( Fig. 3) as described by Falanga and colleagues 4 Complete wound healing was considered as end point of the study.…”

Section: Methodsmentioning

confidence: 99%