Treatment of cognitive dysfunction in adults with major depressive disorder

McIntyre, Roger S.; Syeda, Kahlood; Danielle, S.

doi:10.1017/cbo9781139860567.020

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…During CRT, individuals are instructed to complete a computerized task that stimulates neuroplastic processes in the brain. Regardless of changes in performance over time, the task ensures that users have relatively high success rates to elicit sustained motivation 43 . The ultimate goal of CRT is to develop useful strategies for overcoming cognitively challenging tasks with the support of social networks (eg, therapists and peers).…”

Section: Cognition: Treatmentmentioning

confidence: 99%

Cognitive impairment in major depressive disorder

et al. 2018

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Cognitive dysfunction is a symptomatic domain identified across many mental disorders. Cognitive deficits in individuals with major depressive disorder (MDD) contribute significantly to occupational and functional disability. Notably, cognitive subdomains such as learning and memory, executive functioning, processing speed, and attention and concentration are significantly impaired during, and between, episodes in individuals with MDD. Most antidepressants have not been developed and/or evaluated for their ability to directly and independently ameliorate cognitive deficits. Multiple interacting neurobiological mechanisms (eg, neuroinflammation) are implicated as subserving cognitive deficits in MDD. A testable hypothesis, with preliminary support, posits that improving performance across cognitive domains in individuals with MDD may improve psychosocial function, workplace function, quality of life, and other patient-reported outcomes, independent of effects on core mood symptoms. Herein we aim to (1) provide a rationale for prioritizing cognitive deficits as a therapeutic target, (2) briefly discuss the neurobiological substrates subserving cognitive dysfunction, and (3) provide an update on current and future treatment avenues.

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Section: Cognition: Treatmentmentioning

confidence: 99%

Cognitive impairment in major depressive disorder

et al. 2018

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“…There is an ever-increasing number of interventions available for the management of depression. 4 Pharmacological interventions have been a mainstay of disease management, and recently interest in their use has extended from antidepressant approaches to include procognitive effects. 5 Nonpharmacological interventions have also had a role to play, and techniques such as cognitive behavioral therapy (CBT), cognitive remediation, and electroconvulsive therapy (ECT) have demonstrated evidence of efficacy.…”

Section: Assessing Cognition In Patients With Depressionmentioning

confidence: 99%

“…There is an ever-increasing number of interventions available for the management of depression 4 . Pharmacological interventions have been a mainstay of disease management, and recently interest in their use has extended from antidepressant approaches to include procognitive effects 5 .…”

Section: Assessing Cognition In Patients With Depressionmentioning

confidence: 99%

Screening and measurement of cognitive impairment in psychiatry

Harrison

2019

CNS Spectr.

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A key message from the review of cognitive dysfunction in psychiatry published by Millan et al (2012) was not just that cognitive skills are often compromised in patients with psychiatric disorders, but that deficits in specific domains are common to a number of conditions. The review also highlighted that the magnitude of the observed deficits varied across disorders. A helpful element of the Millan et al study was the inclusion of a table in which the authors sought to convey the domains of cognition and a categorization of the magnitude of the observed deficits.In previous articles, we have considered best practice for the assessment of cognition. In these contributions, we have argued not for the use of specific tests, but instead for measures that meet acceptable standards of reliability, validity, and sensitivity. In the course of our discussions, we have included reference to test validity in the context of considering whether selected measures index appropriate domains of cognition. In this article, we begin with a brief discussion of the requirements for good test selection, especially with respect to issues of sensitivity, reliability, and validity. Thereafter the focus of this article is on the issue of domain validity. We will critically review the specification of the cognitive domains proposed by Millan et al, as well as those selected by authors of meta-analyses characterizing cognitive deficits in major depressive disorders. This focus is solely to make the discussion tractable, though we propose that the issues raised will be applicable across all psychiatric and neurological disorders.

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Relationship between cognitive function and functional outcomes in remitted major depression

Luo,

Fan,

Dou

et al. 2024

BMC Psychiatry

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Background Few studies have focused on functional impairment in depressed patients during symptomatic remission. The exact relationship between cognitive performance and functional outcomes of patients with Major depressive disorder (MDD) remains unclear. Methods Participants diagnosed with MDD were included and interviewed at both baseline and follow-up. Cognitive function was assessed during acute episodes using the Cambridge Neuropsychological Test Automated Battery (CANTAB), which targeted attention (Rapid Visual Processing - RVP), visual memory (Pattern Recognition Memory - PRM), and executive function (Intra-Extra Dimensional Set Shift - IED). The 17-item Hamilton Depression Scale (HAMD) was used for symptom assessment. Participants were divided into two groups based on their SDSS (Social Disability Screening Schedule) scores, and the differences between their demographic information, HAMD scores, and baseline CANTAB test results were compared. Logistic regression analysis was used to identify cognitive predictors of social function during symptomatic remission. Results According to the SDSS score at follow-up, 103 patients were divided into the normal social function group (n = 81,78.6%) and the poor social function group (n = 22, 21.4%) during clinical remission. Participants with poorer social function performed worse in the visual memory (PRM) and executive function tests (IED) at the baseline. Logistic regression analysis suggested that performance on the PRM (95%CI = 0.31–0.93, p = 0.030) and IED (95%CI = 1.01–1.13, p = 0.014) tests, instead of less severe symptoms, significantly contributed to functional outcomes. Conclusion Better performance in visual memory and executive function during acute episodes may predict better social functional outcomes in individuals with MDD. A potential early intervention to improve social function in individuals with MDD could include the treatments for executive function and visual memory.

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Treatment of cognitive dysfunction in adults with major depressive disorder

Cited by 3 publications

References 39 publications

Cognitive impairment in major depressive disorder

Cognitive impairment in major depressive disorder

Screening and measurement of cognitive impairment in psychiatry

Relationship between cognitive function and functional outcomes in remitted major depression

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