Treatment of complicated Candida vaginitis: Comparison of single and sequential doses of fluconazole

In Vitro and in Vivo Antifungal Activities of the Eight Steroid Saponins from Tribulus terrestris L. with Potent Activity against Fluconazole-Resistant Fungal

“…Candidal vaginitis is predominantly caused by strains of C. albicans (90%), [5][6][7] and remains to be a common problem in immunocompetent or healthy women. So we also observed the in vivo activity of TTS-12 against fluconazole-resistant C. albicans.…”

Fluconazole Susceptibility of Vaginal Isolates Obtained from Women with Complicated Candida Vaginitis: Clinical Implications

“…In vitro fluconazole resistance developed in 2 of 18 initially susceptible C. glabrata isolates following fluconazole exposure. Susceptibility testing for women with complicated Candida vaginitis appears to be unjustified.Candida vaginitis remains a common problem in immunocompetent, healthy women and is predominantly caused by strains of Candida albicans (Ͼ90%) (14,17,19). Only a minority of cases (Ͻ10%) are caused by non-C. albicans Candida species, usually C. glabrata, and despite considerable debate, there is little evidence of a significant increase in infection rates due to the non-C. albicans Candida species (14,17,19).…”

“…Only a minority of cases (Ͻ10%) are caused by non-C. albicans Candida species, usually C. glabrata, and despite considerable debate, there is little evidence of a significant increase in infection rates due to the non-C. albicans Candida species (14,17,19). Given the reports of refractory oral and esophageal candidiasis caused by fluconazole-resistant C. albicans strains and, less commonly, non-C. albicans Candida species, it is important to monitor the fluconazole susceptibilities of vaginal isolates of the various Candida species (1,3,5,8,11).…”

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“…The long duration of treatment ≥ 6 months has the potential of impacting on compliance, which may worsen recurrences. It may also lead to colonisation with less susceptible Candida spp or development of resistance among usually susceptible Candida albicans strains and ultimately to refractory candidiasis [11,145]. The fact that there is no cure even after such a prolonged treatment course, with 60-70% having a recurrent episode within two months [94,116], may lead to frustration among the patients who may not accept and/or use antifungals for the next episode.…”