Treatment of Corrosive Burns of the Esophagus

Beneficial effects of Ebselen on corrosive esophageal burns of rats

“…Theoretically, antireflux therapy, systemic antibiotics, and corticosteroids should help minimize esophageal stricture formation. Anti-reflux therapy prevents further chemical trauma, antibiotics decrease bacterial infection, and corticosteroids inhibit inflammation and collagen deposition [24][25][26]. Anderson et al [27] reported an 18 year prospective controlled trial of long-term corticosteroids and antibiotics (for 5-6 weeks, including steroid taper) in 60 children with corrosive injury of the esophagus.…”

A case of esophageal stricture after corrosive esophagitis successfully treated by frequent endoscopic balloon dilation

“…Accidental cases are usually observed in children. Campbell et al reported that 80% of hospitalized patients with corrosive esophagitis were less than 10 years of age [1]. Damage to the gastrointestinal wall caused by an alkali is generally more severe than that caused by an acid, and corrosive esophagitis caused by an alkaline solution can therefore result in severe esophageal stricture.…”

“…Symbas et al reported that 74 of 176 patients who had swallowed corrosive agents had esophagitis as determined by endoscopy and that esophageal stricture occurred in 29 of those 74 patients [2]. Treatments for esophageal stricture include conservative treatments such as bougie or balloon dilation, but when the stricture is long and severe, most cases need to be treated by surgical resection and reconstruction of the esophagus or a who had swallowed an alkaline solution; 2 of those 18 patients could be treated conservatively but 10 patients who had long and severe strictures require esophageal resection and reconstruction using colon [1]. They also reported that surgical treatment is much better than treatment by the use of a bougie for case of long and severe esophageal stricture because of the risk of perforation.…”

“…The damage is usually more severe in the esophagus than in stomach, because an alkali is neutralized by acid in the stomach. Esophageal stricture is treated by resection and reconstruction of the esophagus or conservatively by dilation using a bougie or balloon [1,2]. There have been few reports of successful results of conservative treatment [1,2].…”

“…Esophageal stricture is treated by resection and reconstruction of the esophagus or conservatively by dilation using a bougie or balloon [1,2]. There have been few reports of successful results of conservative treatment [1,2]. We experienced a case of esophageal stricture after caustic esophagitis in a 14-year-old girl that was successfully treated by frequent endoscopic balloon dilation and tranilast medication.…”