Treatment of depression in patients with temporal lobe epilepsy: A pilot study of cognitive behavioral therapy vs. selective serotonin reuptake inhibitors

Orjuela-Rojas, Juan Manuel; Martínez‐Juárez, Iris E.; Ruiz-Chow, Ángel; Crail-Meléndez, Daniel

doi:10.1016/j.yebeh.2015.07.033

Cited by 29 publications

(37 citation statements)

References 37 publications

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“…Together these studies examined 1,969 participants receiving CBT and 4,286 participants receiving SSRI treatment. Of note, only two studies directly examined the effects of both SSRI and CBT for depression on QOL (Farabaugh et al, 2015; Orjuela-Rojas, Martínez-Juárez, Ruiz-Chow & Crail-Melendez, 2015). In order to avoid double counting these studies by using them for analyses of both treatment modalities, we excluded it from our analyses.…”

Section: Resultsmentioning

confidence: 99%

“…Of those, 37 studies (24 CBT, 13 SSRI) examining 1,969 participants receiving CBT and 4,286 participants receiving SSRI treatment were used for this meta-analytis. Only two studies directly examined the effects of SSRI and CBT for depression on QOL (Farabaugh, et al, 2015; Orjuela-Rojas et al, 2015), and as described above were not included in the analysis. Therefore, this research was not designed to directly compare the effects of CBT vs. SSRIs for depression on QOL.…”

Section: Discussionmentioning

confidence: 99%

“…The authors found no statistically significant differences between treatment groups on any of the outcome measures, including QOL. The study by Orjuela-Rojas et al (2015) randomized patients with temporal lobe epilepsy to receive 12 weeks of CBT (n = 7) or SSRI (n = 8) for the treatment of major depressive disorder. After treatment, both groups showed improved QOL and reduced severity of depression symptoms, with no statistically significant group differences.…”

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confidence: 99%

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Effect of treatments for depression on quality of life: a meta-analysis

Hofmann

Curtiss

Carpenter

et al. 2017

Cognitive Behaviour Therapy

123

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BACKGROUND Cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are the two first-line treatments for depression, but little is known about their effects on quality of life. AIMS To investigate the efficacy of these two interventions for depression on quality of life (QOL). METHOD A meta-analysis was conducted to examine changes in QOL in adults with major depressive disorder who received CBT (24 studies examining 1,969 patients) or SSRI treatment (13 studies examining 4,286 patients) for their depression. RESULTS Moderate improvements in QOL from pre to post-treatment were observed in both CBT (Hedges’ g = 0.63) and SSRI (Hedges’ g = 0.79) treatments. The effect size remained stable over the course of the follow-up period for CBT. No data were available to examine follow-ups in the SSRI group. QOL effect sizes decreased linearly with publication year, and greater improvements in depression were significantly associated with greater improvement in QOL for CBT, but not for SSRIs. CONCLUSION CBT and SSRIs for depression were both associated with moderate improvements in QOL, but are possibly caused by different mechanisms.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of treatments for depression on quality of life: a meta-analysis

Hofmann

Curtiss

Carpenter

et al. 2017

Cognitive Behaviour Therapy

123

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“…Only 1 RCT investigated a psychological intervention specifically aiming to decrease anxiety symptoms . Four studies investigating psychological interventions, 1 study investigating a self‐management program, and 1 study investigating an educational program measured anxiety symptoms as a secondary outcome. Three studies were LOE II, and 1 study was LOE III, whereas the remaining 3 studies were LOE IV .…”

Section: Available Evidence For Psychological Treatment Across the Epmentioning

confidence: 99%

Psychological treatments for adults and children with epilepsy: Evidence‐based recommendations by the International League Against Epilepsy Psychology Task Force

et al. 2018

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Given the significant impact that psychosocial factors and epilepsy treatments can have on the health-related quality of life (HRQOL) of individuals with epilepsy and their families, there is great clinical interest in the role of psychological evaluation and treatments to improve HRQOL and comorbidities. Therefore, the International League Against Epilepsy (ILAE) charged the Psychology Task Force with the development of recommendations for clinical care based on evaluation of the evidence from their recent Cochrane review of psychological treatments in individuals with epilepsy. The literature search for a recent Cochrane review of randomized controlled trials investigating psychological treatments for individuals with epilepsy constitutes the key source of evidence for this article. To provide practical guidance to service providers, we provide ratings on study research designs based on (1) the American Academy of Neurology's Level of Evidence system and (2) the Grading of Recommendations, Assessment, Development, and Evaluation system. This paper is the culmination of an international collaboration process involving pediatric and adult psychologists, neurologists, psychiatrists, and neuropsychiatrists. The process and conclusions were reviewed and approved by the ILAE Executive Committee. The strongest evidence for psychological interventions was identified for the most common mental health problems, including depression, neurocognitive disturbances, and medication adherence. Psychological interventions targeting the enhancement of HRQOL and adherence and a decrease in comorbidity symptoms (anxiety, depression) should be incorporated into comprehensive epilepsy care. There is a range of psychological strategies (ie, cognitive behavioral therapy and mindfulness-based therapies) that show promise for improving the lives of persons with epilepsy, and clinical recommendations are provided to assist epilepsy health care providers in treating the comorbidities and challenges associated with epilepsy and its treatments.

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“…In 1994, the clinical investigation by Denicoff et al [106] revealed that carbamazepine had a significant effect on 67.5% of epileptics with acute bipolar depression and 32.2% of epileptics with unipolar depression. In 2015, Orjuela-Rojas et al [110] compared the different effects between SSRIs and CBTs for MDD in patients with temporal lobe epilepsy. The results showed that the severity of depressive symptoms decreased and the quality of life (QOL) improved in both groups, but there were no significant differences between the two treatments.…”

Section: Diagnosismentioning

confidence: 99%

The comorbidity of epilepsy and depression: diagnosis and treatment

Tao

Wang

2016

Expert Review of Neurotherapeutics

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Depression can seriously affect the quality of life of epileptic patients and can even lead to suicide. Understanding the regularity, prevention and treatment of depression in patients with epilepsy (PWE) contributes to the improvement of their quality of life. Areas covered: In this paper, we retrospectively analyzed the relevant literature on the pathogenesis, related factors, clinical characteristics, diagnosis and treatment of depression in PWE. A literature search utilized the PubMed, Embase and Google Scholar databases. Expert commentary: PWE often have depression, which can be the result of seizures, antiepileptic drugs (AEDs) or social-demographic factors. It needs to be better understood, and the diagnosis should be more comprehensive for early treatment.

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Treatment of depression in patients with temporal lobe epilepsy: A pilot study of cognitive behavioral therapy vs. selective serotonin reuptake inhibitors

Cited by 29 publications

References 37 publications

Effect of treatments for depression on quality of life: a meta-analysis

Effect of treatments for depression on quality of life: a meta-analysis

Psychological treatments for adults and children with epilepsy: Evidence‐based recommendations by the International League Against Epilepsy Psychology Task Force

The comorbidity of epilepsy and depression: diagnosis and treatment

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