Treatment of depression with anti‐inflammatory medications—the role of pain relief

Meta‐analysis of antidepressant effects of anti‐inflammatory drugs—reply

“…Hence, the area of anti-inflammatory treatment for depression represents an interesting field with promising findings, where our meta-analysis contributes with proof of concept regarding the potential of anti-inflammatory agents in the treatment of depression. Nonetheless, we very much agree with Dr. Balon (1) and Drs. Baldessarini and V azquez (2) that a cautious approach is necessary and most helpful for patients and that several important questions need to be addressed before recommending clinical use.…”

“…We thank Dr. Balon (1) and Drs. Baldessarini and V azquez (2) for their letters concerning our meta-analysis of randomized clinical trials (RCTs) showing antidepressant effects of anti-inflammatory agents (3).…”

“…Baldessarini and V azquez (2) that a cautious approach is necessary and most helpful for patients and that several important questions need to be addressed before recommending clinical use. The placebo-controlled, relapse prevention studies (PCRPS) have recently been singled out as redundant, disproportionately harmful, unnecessary and therefore ethically impermissible (1). The logic of comparison behind PCRPS has also been questioned as they apply different methodological procedures, such as duration of treatment prior to randomization and/or different treatment discontinuation strategies (2).…”

Predicting the Mechanism of the Analgesic Property of Yanhusuo Based on Network Pharmacology

“…Finally, an interaction network of the component-target-pathway of Yanhusuo was constructed, and the functions and pathways were analyzed for preliminarily investigating the mechanism of Yanhusuo in analgesia. The results showed that the active components of analgesic in Yanhusuo were Corynoline, dehydrocorydaline, saulatine,2,3,9,isoquinolin-8-on-e, and Capaurine. The mechanisms were involved in metabolic pathways, PI3k-Akt signaling pathway, pathways in cancer, and so on.…”

“…Analgesics mainly act on the central or peripheral nervous systems by selectively inhibiting and relieving from various kinds of pain. 2 The chemical constituents of Yanhusuo are complex, and include alkaloids, polysaccharides, resins, volatile oils, and inorganic trace elements. The main components in Yanhusuo include protoberberine alkaloid tetrahydroprotoberberine alkaloids, protopine alkaloids, and aporphine alkaloids.…”