Treatment of Dupuytren's disease using collagenase from Clostridium histolyticum

Martín-Ferrero, Miguel Ángel; Simón-Pérez, Clarisa; Rodríguez-Mateos, J.I.; García-Medrano, B.; Hernández-Ramajo, Rubén; Brotat-García, M.

doi:10.1016/j.recote.2013.11.002

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…Gender data were not available in 12 studies. [15][16][17][18][19][20][21][22][23][24][25][26] The average age of the patients at the treatment time was 64 years; the mean follow-up was 15 months, ranging from 1 to 96 months. 15…”

Section: Resultsmentioning

confidence: 99%

“…Eighteen studies considered the clinical satisfaction of the patients and a residual contracture <5°as primary end points (Table 2). 16 4 Case series 42 Rozen et al 17 12 12 Case series 54 Coleman et al 33 12 1 Case series 57 Peimer et al 34 463 Retrospective case control 55 Sanjuan-Cerverò et al 18 91 Retrospective case control 65 Hayton et al 35 616 Retrospective case control 60 Martin Ferrero et al 19 35 Prospective case series 47 Nydick et al 36 59 6…”

Section: Objective Outcomementioning

confidence: 99%

“…Retrospective case series 50 Mehta et al 44 40 Cost analysis Mc Grouther et al 24 58 12 Case series 87 Coleman et al 25 60 2 Case series 71 Alberton et al 45 Gilpin et al 30 reported the worst percentage of clinical success for both MP (13/20; 65%) and PIP (7/25; 28%); Badalamente et al 27 reported the best result for MP (18/18; 100%) and in 2007 for PIP (9/9; 100%). Several studies (Table II and 13,16,19,22,23,33,35,37,[41][42][43]49,50,[54][55][56] ) reported secondary end points, described as clinical improvement, but these results are difficult to compare because different variables such as range of motion (ROM) changes and decreased contracture were considered. Some studies 15,17,39,53 did not report objective outcomes.…”

mentioning

confidence: 99%

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Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review

Smeraglia

Buono²,

Maffulli

2016

Br Med Bull

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Section: Resultsmentioning

confidence: 99%

Section: Objective Outcomementioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review

Smeraglia

Buono²,

Maffulli

2016

Br Med Bull

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“…Although some side reactions have been noted for injectable C. histolyticum collagenase like skin lacerations, edema, hemorrhage, injection site pain and bruising and less frequently tendon and pulley rupture [17,18], its effectiveness has been proved by several in vivo studies [19,20], with contracture reduction in more than 60% of the patients injected with injectable clostridial collagenase [16]. Collagenase injection is more worthwhile than surgical fasciotomy [20], has less and milder side-effects, and demonstrated a better total reduction of Dupuytren's contracture leading to higher patient satisfaction [21].…”

Section: Dupuytren's Disease (Dd)mentioning

confidence: 99%

Microbial Enzymes: Therapeutic Applications

Reshma

2019

MRJI

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Enzymes are biomolecules with highly specialized catalytic functions produced by all living organisms and are responsible for biochemical reactions in plants, animals, microorganisms and human beings. Nowadays enzymes are considered as core of biotechnology because they are the main tools for the application of basic biotechnological techniques, they act as the target of the therapeutic drugs and are indispensable intermediates in all biotechnological processes. The concept of the therapeutic enzymes has been around for at least 40 years. Microbial enzymes are preferred over other sources and in this review different types of microbial enzymes are discussed for their therapeutic applications.

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“…Essa condição pode variar desde pequenos nódulos até faixas muito espessas, as quais podem tracionar dos dedos em direção à palma da mão (Martin-Ferrero et al, 2013, Peimer et al, 2013, Hentz, 2014, Meals and Hentz, 2014, Leclère et al, 2014, na osteoartrite (Adães et al, 2015), no tratamento de miomas uterinos (Jayes et al, 2016) e na remodelagem da matrix extracelular no câncer colorretal (Jucá et al, 2008).…”

Section: Aplicações Na Indústria Biomédica E Terapêuticaunclassified

Colagenasas do pescado y sus aplicaciones industriales

Oliveira

Cunha

Assis

et al. 2017

Pubvet

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RESUMO.Colagenases são grupos de enzimas capazes de clivar a tripla-hélice do colágeno não tendo ação sobre outro tipo de proteína. São obtidas a partir de uma vasta gama de fontes, tais como tecido animal e vegetal. Uma fonte promissora na atualidade é a partir de resíduos negligenciados do processamento do pescado, tais como vísceras internas (intestino). Esta revisão objetivou realizar um levantamento quantitativo da produção cientifica relacionada à colagenase do pescado, bem como dissertar sobre as principais características bioquímicas e aplicações industriais dessa protease, com ênfase nas colagenases extraídas a partir de organismos aquáticos. Dessa forma, através de análise do Scopus, no período de 1963 a 2016, foram detectadas 274 citações ao termo "collagenase fish". A produção cientifica pertinente a colagenase do pescado está intrinsicamente relacionada a necessidade industrial de fontes alternativas dessas proteases colagenolíticas, devido sua extensa aplicação industrial, tais como nos segmentos alimentícios, biomédicos, terapêuticos e têxtil.Palavras chave: Biotecnologia, enzimas, pescado, protease, resíduos Fish collagenases and its industrial applicationsABSTRACT. Collagenases are a group of enzymes capable of cleaving the triple-helix collagen, having no action on another type of protein. They are obtained from a wide range of sources, such as animal and plant tissue. A promising source at present is from neglected fish processing residues, such as internal viscera (intestine). This review aimed to quantify the scientific production related to fish collagenase, as well as to discuss the main biochemical characteristics and industrial applications of this protease, with emphasis on collagenases extracted from aquatic organisms. Thus, through analysis of Scopus, from 1963 to 2016, 274 citations were detected to the term "collagenase fish". The scientific production relevant to fish collagenase is intrinsically related to the industrial need for alternative sources of these collagenolytic proteases, due to their extensive industrial application, such as in the food, biomedical, therapeutic and textile segments.

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Treatment of Dupuytren's disease using collagenase from Clostridium histolyticum

Cited by 8 publications

References 11 publications

Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review

Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review

Microbial Enzymes: Therapeutic Applications

Colagenasas do pescado y sus aplicaciones industriales

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