Treatment of essential thrombocythemia with anagrelide

Successful treatment of essential thrombocythemia with anagrelide in a child

“…In the series of Meisel et al [16], 11 out of 35 patients were asymptomatic, and 66% of patients presented with thrombosis-related symptoms, most commonly neurological, microcirculatory, or thromboembolic. Our patient, like two of the three patients of Chintagumpala et al [4], presented with severe headaches and abdominal pain.…”

“…Chintagumpala et al [3] published successful treatment of ET with anagrelide in an 11-year-old boy in 1991; and in 1995, successful treatment of two further children [4]. The anagrelide study group reported on 577 patients with myeloproliferative diseases, including 335 patients with ET in 1992 [5].…”

“…The main conditions (Table I) accompanied by reactive or secondary thrombocytosis are: iron deficiency anemia, acute blood loss, postsplenectomy state, infectious or inflammatory states, and in the period after aplastic crises in children with chronic hemolytic anemias or in the regeneration phase after transient erythroblastopenia of childhood. The complete loss of platelet aggregation responses to adrenalin, accompanied by normal aggregation patterns with other antiaggregating compounds, is virtually diagnostic and is useful in discriminating essential thrombocythemia from reactive thrombocythemia [4]. Other chronic myeloproliferative diseases (CMPDs) are extremely rare in childhood, but must be excluded.…”

“…The leukocyte alkaline phosphate level, which is pathognomonically low in chronic myeloid leukemia but normal in ET, is helpful in distinguishing between these related disorders [4].…”

“…When the prelate came across the Italian name ''Brontë,'' he thought it more fitting, while also a near homonym and homophone (Greek: homo ‫ס‬ same + onyma ‫ס‬ name + phone ‫ס‬ sound). 4 A dictionary (Latin: dico ‫ס‬ say) is better termed a lexicon (Greek: lexikos ‫ס‬ of words) because compendia of this kind deal and have dealt with much more than how to pronounce words. It is true that in the early years of English lexicography, stress was placed on pronunciation, particularly in the dictionaries published by the actors Thomas Sheridan (1780) and John Walker (1791).…”