The treatment of highly alkaline and toxic industrial organic raffinate (IOR) containing pyridine and its derivatives was studied by coupling of catalytic wet air oxidation (CWAO) and a biological process. The CWAO of IOR was performed using 1 wt % platinum catalyst to degrade toxic compounds present in the IOR to biodegradable intermediates. The prepared catalyst was characterized using scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction analysis. Highpressure liquid chromatography of CWAO-treated effluent showed complete degradation of pyridine. The toxicity of the CWAOtreated effluent was checked, and it was found to be nontoxic. The CWAO-treated effluent was post-treated using biological method, and the final effluent was found to be within discharge limits prescribed by the statutory authorities. The reusability of the catalyst was studied, and the catalyst was found effective for four cycles. The present study suggests an effective solution for addressing toxic organic pollutants in wastewater.