Treatment of experimental renal hypertension with partially purified renin

Wakerlin, G. E.; Johnson, Clarence A.; Smith, E. L.; Gomberg, Bryon R.; Weir, Jane; Moss, W. G.; Goldberg, Marvin

doi:10.1016/s0002-8703(43)90378-3

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1943

1953

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“…The serum of treated dogs was assayed for possible pressor neutralizing effects by the method usually employed for the determination of antirenin. 3 Precipitin tests were carried out in the usual manner. Amine sensitivity patterns were determined by the intravenous injection of a given amine and the simultaneous measurement of blood pressure in the unanesthetized, trained dog.…”

Section: Methodsmentioning

confidence: 99%

Amines in Experimental Hypertensions

Ohler

Wakerlin

1953

Circulation Research

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A sympathomimetic amine, Paredrine, was shown to be a good antihypertensive agent in experimental renal, experimental neurogenic and spontaneous hypertensions in the dog. Other closely related amines failed to possess antihypertensive activity. Paredrine did not prevent the development of experimental renal hypertension. This amine was also without chronic effect on the blood pressure of normotensive dogs.

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Section: Methodsmentioning

confidence: 99%