Antirenin to hog renin produced in the dog neutralizes the acute pressor effect of dog as well as hog renin. A course of intramuscular injections of hog renin in chronic renal hypertensive dogs produces an antihypertensive effect which is correlated with the antirenin titers of the plasma. Passive transfer of high titer homologous antiserum to hog renin produces an antihypertensive effect in chronic renal hypertensive dogs which is correlated with the antirenin titer. The results suggest a pathogenetic role for renin in experimental renal hypertension in the dog.

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The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

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