Treatment of External Genital Warts Comparing Cryotherapy (Liquid Nitrogen) and Trichloracetic Acid

Abdullah, Adel Néma; WALZMAN, MICHAEL; Wade, A

doi:10.1097/00007435-199320060-00008

Cited by 88 publications

(28 citation statements)

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“…13,16,18,19,31 In randomized controlled trials using cryotherapy for GWs, clearance rates of 54- 88% and recurrence rates of 21-40%, have been reported with monotherapy. 18,20 …”

Section: Discussionmentioning

confidence: 99%

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A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men

Camargo

Belda

Fagundes

et al. 2014

An. Bras. Dermatol.

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BACKGROUNDGenital warts are caused by human papillomavirus infection and represent one of the most common sexually transmitted diseases. Many infections are transient but the virus may recur, persist, or become latent. To date, there is no effective antiviral treatment to eliminate HPV infection and most therapies are aimed at the destruction of visible lesions. Potassium hydroxide is a strong alkali that has been shown to be safe and effective for the treatment of genital warts and molluscum contagiosum. Cryotherapy is considered one of the most established treatments for genital warts. No comparative trials have been reported to date on the use of potassium hydroxide for genital warts.OBJECTIVEA prospective, open-label, randomized clinical trial was conducted to compare topical potassium hydroxide versus cryotherapy in the treatment of genital warts affecting immunocompetent, sexually active men.METHODSOver a period of 10 months, 48 patients were enrolled. They were randomly divided into two groups and selected on an alternative basis for either potassium hydroxide therapy or cryotherapy. While response to therapy did not differ substantially between both treatment modalities, side effects such as local pain and post-treatment hypopigmentation were considerably more prevalent in the groups treated using cryotherapy.RESULTIn our study, potassium hydroxide therapy proved to be at least as effective as cryotherapy and offered the benefit of a better safety profile.CONCLUSIONTopical 5% potassium hydroxide presents an effective, safe, and low-cost treatment modality for genital warts in men and should be included in the spectrum of therapies for genital warts.

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“…13,16,18,19,31 In randomized controlled trials using cryotherapy for GWs, clearance rates of 54- 88% and recurrence rates of 21-40%, have been reported with monotherapy. 18,20 …”

Section: Discussionmentioning

confidence: 99%

“…16-20 It has been shown to be superior to electrodessication and podophyllin. 21,22 Systemic side effects do not occur.…”

Section: Introductionmentioning

confidence: 99%

A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men

Camargo

Belda

Fagundes

et al. 2014

An. Bras. Dermatol.

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“…Cryotherapy alone is used most frequentlyand has a reported efficacy of 79–88% for wart clearance, but as with all therapies relapse or recurrence is frequent, occurring in 25–39% of cases 4 5 6. Multiple attendances are often needed, which increases the burden on both patients and clinic resources.…”

mentioning

confidence: 99%

A multicentre, randomised, double-blind, placebo controlled study of cryotherapy versus cryotherapy and podophyllotoxin cream as treatment for external anogenital warts

Gilson

Ross²,

Maw

et al. 2009

Sexually Transmitted Infections

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Results: 70 patients per group were randomised and started treatment; 101 firstepisode warts, 91 male. No treatment-related serious adverse events were reported.Follow-up at week 12 was 85%. By intention-to-treat analysis, clearances at 4 and 12 weeks were higher in the combination group (60.0% and 60.0% respectively) than with cryotherapy alone (45.7%, 45.7%) although not statistically significant (relative risk 1.31; 95% CI 0.95, 1.81). By week 24 there was no difference between the groups (68.6% and 64.3% respectively, RR 1.07; CI 0.84, 1.35). At week 4, wart clearance was higher in men (p=0.001) and those with a past history of warts (p=0.009), but these differences were not detected at week 12. There was some evidence for a higher relapse rate in the group receiving cryotherapy alone. Conclusions:Initial combination therapy with podophyllotoxin/cryotherapy was well tolerated and may have resulted in earlier clearance in some patients, compared to cryotherapy alone, however overall differences in clearance rates were not statistically significant.3

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“…It is most suitable for small condylomata warts and is less efficacious on keratinized or large lesions (32,33). It is applied to the wart at weekly intervals as an 80-90% solution using a cotton tip.…”

Section: Topical Office Therapy Trichloracetic Acid Against Limited Dmentioning

confidence: 99%

The Management and Prevention of Premalignant Penile Lesions

Horenblas

Krogh

2000

Scandinavian Journal of Urology and Nephrology

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Treatment of External Genital Warts Comparing Cryotherapy (Liquid Nitrogen) and Trichloracetic Acid

Cited by 88 publications

References 0 publications

A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men

A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men

A multicentre, randomised, double-blind, placebo controlled study of cryotherapy versus cryotherapy and podophyllotoxin cream as treatment for external anogenital warts

The Management and Prevention of Premalignant Penile Lesions

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