Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar

Wirth, Alfred; Middelhoff, G.; Braeuning, Ch.; Schlierf, G.

doi:10.1016/0021-9150(82)90230-1

Cited by 24 publications

(26 citation statements)

References 12 publications

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“…The only findings to contrast with these observations are those in which the fiber derived from natural foods or where a significant portion of the fiber was insoluble. In these cases, studies have been unable to show a reduction in serum lipids (4,5,74,94,(105)(106)(107)(108)(109)(110)(111)(112)(113)(114).…”

Section: Fiber Supplementsmentioning

confidence: 99%

Dietary Fiber in Management of Diabetes

1988

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Current evidence suggests that high-fiber diets, especially of the soluble variety, and soluble fiber supplements may offer some improvement in carbohydrate metabolism, lower total cholesterol and low-density lipoprotein (LDL) cholesterol, and have other beneficial effects in patients with non-insulindependent diabetes mellitus (NIDDM). Diets enriched with wheat bran and guar gum induce 10-20% reductions in serum cholesterol and LDL in both normoand hypercholesterolemic subjects and have the ability to blunt the hypertriglyceridemic effects of diets high in carbohydrate and low in fiber. In insulin-dependent diabetes mellitus (IDDM) the situation is less clear, but a decrement of the circadian glucose profile has been shown. Americans, in general, consume too little fiber. With the need to restrict fat and reduce protein, an increase in carbohydrates is mandatory. A practical goal would be to establish the present level of fiber intake (15-30 g/day) and to gradually increase it. An intake of up to 40 g of fiber per day or 25 g/1000 kcal of food intake appears beneficial; in many individuals on weight-reducing diets higher levels may be unacceptable because of gastrointestinal side effects. The level of maximum benefit has not been determined. Fiber supplementation appears beneficial only if given with a diet comprising approximately half of the calories as carbohydrate. Foods should be selected with moderate to high amounts of dietary fiber from a wide variety of choices to include both soluble and insoluble types of fiber. Insufficient data are available on the long-term safety of high-fiber supplements. People at risk for deficiencies, such as postmenopausal women, the

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Section: Fiber Supplementsmentioning

confidence: 99%

Dietary Fiber in Management of Diabetes

1988

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“…These findings are corroborated by other reports in the literature. [66][67][68] In addition, it has been suggested that guar gum may cause possible drug interactions such as the potentiation of the effects of insulin. 69 There are similarly findings with respect to chromium picolinate (Table 1), whose data suggest risks caused by chromosome damage.…”

Section: Discussionmentioning

confidence: 99%

Complementary therapies for reducing body weight: a systematic review

2005

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The prevalence of obesity is increasing at an alarming rate and a plethora of complementary therapies are on offer claiming effectiveness for reducing body weight. The aim of this systematic review is to critically assess the evidence from randomized controlled trials (RCTs) and systematic reviews of complementary therapies for reducing body weight. Literature searches were conducted on Medline, Embase, Amed, and the Cochrane Library until January 2004. Hand-searches of relevant medical journals and bibliographies of identified articles were conducted. There were no restrictions regarding the language of publication. Trial selection, quality assessment and data abstraction were performed systematically and independently by two authors. Data from RCTs and systematic reviews, which based their findings on the results of RCTs, were included. Six systematic reviews and 25 additional RCTs met our inclusion criteria and were reviewed. The evidence related to acupuncture, acupressure, dietary supplements, homeopathy and hypnotherapy. Except for hypnotherapy, Ephedra sinica and other ephedrine-containing dietary supplements the weight of the evidence is not convincing enough to suggest effectiveness. For these interventions, small effects compared with placebo were identified. In conclusion, our findings suggest that for most complementary therapies, the weight of the evidence for reducing body is not convincing. Hypnotherapy, E. sinica and other ephedrine-containing dietary supplements may lead to small reductions in body weight. However, the intake of E. sinica and ephedrine is associated with an increased risk of adverse events. Interventions suggesting positive effects in single RCTs require independent replication.

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“…Jenkins et al (1975) originally observed a hypocholesterolaemic effect of guar gum, a water soluble noncellulosic polysaccharide. Since then, many studies have con®rmed that guar gum can reduce total cholesterol and LDL concentrations in normal subjects (Smith and Holm, 1982;Penagini et al, 1986) and in hyperlipidaemic subjects (Wirth et al, 1982;Aro et al, 1984). Also, soluble ®bre in oats, rye and barley has been shown to reduce serum cholesterol concentrations, although high quantities of those products are needed for signi®cant effects (van Horn et al, 1986;Turnbull & Leeds, 1987).…”

Section: Discussionmentioning

confidence: 99%