2016
DOI: 10.1016/j.joca.2015.09.009
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Treatment of full thickness focal cartilage lesions with a metallic resurfacing implant in a sheep animal model, 1 year evaluation

Abstract: Our results showed a consistent and accurate placement of these implants at a defined zone. At this position cartilage wear of opposing and surrounding joint cartilage is limited. Thus expanded animal and human studies are motivated.

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Cited by 43 publications
(50 citation statements)
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“…Additionally, tissue opposing damaged cartilage presented signs of early degeneration in a goat model with intact joint stability, 20 weeks after defect creation [ 72 ]. Similar results were observed for cartilage tissue opposing a metallic resurfacing implant in a goat and sheep model, 1-year after surgery [ 73 , 74 ]. For further validation of these insights in vivo in subjects presenting isolated cartilage defects in the knee joint, the longitudinal use of fluoroscopy [ 75 ] and dynamic MRI [ 76 ], including DENSE imaging [ 77 ], should be considered to non-invasively estimate the local material properties based on estimated or measured deformation.…”
Section: Discussionsupporting
confidence: 77%
“…Additionally, tissue opposing damaged cartilage presented signs of early degeneration in a goat model with intact joint stability, 20 weeks after defect creation [ 72 ]. Similar results were observed for cartilage tissue opposing a metallic resurfacing implant in a goat and sheep model, 1-year after surgery [ 73 , 74 ]. For further validation of these insights in vivo in subjects presenting isolated cartilage defects in the knee joint, the longitudinal use of fluoroscopy [ 75 ] and dynamic MRI [ 76 ], including DENSE imaging [ 77 ], should be considered to non-invasively estimate the local material properties based on estimated or measured deformation.…”
Section: Discussionsupporting
confidence: 77%
“…In order to fill this gap, an innovative, patient-specific metal implant (Episealer) has been designed from MRI-images and the lesion-size, and ongoing CPL (Controlled Product Launch) is taking Place, with almost 2-year follow-up. [11][12][13][14]15,17,18] the aim of this study is to present a case report of the first "Danish patient" with 3 year clinical and radiographic follow-up of this new resurfacing mini-prosthesis [18].…”
Section: Objectivementioning
confidence: 99%
“…Most FKRIs approved for clinical use are metal‐based, comprising a highly polished cobalt‐chromium articulating top to substitute cartilage and a titanium bone‐substituting base (Fuchs et al, 2018; Pascual‐Garrido, Daley, Verma, & Cole, 2017; Skoldenberg et al, 2014; Stalman et al, 2018). A primary prerequisite for FKRIs is adequate fixation in the subchondral bone, in order to maintain congruency to the articular surface (Martinez‐Carranza et al, 2016; Stalman et al, 2018). Multiple studies have proven excellent osseointegration of titanium‐based FKRIs (Custers et al, 2010; Martinez‐Carranza et al, 2014; Stalman et al, 2018).…”
Section: Introductionmentioning
confidence: 99%