Treatment of GABA from Fermented Rice Germ Ameliorates Caffeine-Induced Sleep Disturbance in Mice

Mabunga, Darine Froy N.; Gonzales, Edson Luck; Kim, Hee Jin; Choung, Se‐Young

doi:10.4062/biomolther.2015.022

Cited by 39 publications

(19 citation statements)

References 45 publications

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“…Some crude drugs contained in YKSCH (Bupleurum root, Japanese angelica root, and Cnidium rhizome) are reported to have compounds that bind to the GABA binding sites of the GABA A receptor in a receptor binding assay (25). According to previous studies, oral administration of GABA prolonged pentobarbital-induced sleep duration in group-housed mice (26). Though Yokukansan includes water-soluble botanic GABA (27), orally administered GABA does not cross the blood-brain barrier efficiently, and YKSCH treatment could not prolong the sleeping time in group-housed mice (Figure 2).…”

Section: Discussionmentioning

confidence: 75%

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Yokukansankachimpihange Improves the Social Isolation-Induced Sleep Disruption and Allopregnanolone Reduction in Mice

Murata¹,

Li²,

Shinguchi³

et al. 2020

Front. Nutr.

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Yokukansankachimpihange (YKSCH), a traditional Japanese medicine composed of 9 crude drugs, is designed to improve neurosis, insomnia in adults, and night crying in children. YKSCH has been reported to improve diurnal rhythm in patients with Alzheimer's disease and prolong the total sleeping time in healthy subjects. However, little is known about how YKSCH alleviates sleep disorders. Here, we investigated whether and how YKSCH treatment affected sleep latency and duration in group-housed and socially isolated mice. Male ddy mice were treated with YKSCH [1,500 mg/kg, per os (p.o.)] in group-housed or socially isolated conditions for 3-4 weeks. After the last injection, mice were intraperitoneally (i.p.) administered with pentobarbital (60 mg/kg) and the sleep latency and duration was evaluated. The results show that pretreatment with YKSCH had no effect on sleep latency or duration in group-housed mice. However, YKSCH treatment significantly improved the reduced sleep duration in socially isolated mice. This effect of YKSCH was inhibited by the administration of bicuculline (3 mg/kg, i.p.), a GABA A receptor antagonist. Furthermore, we showed that YKSCH treatment improved the decrease in allopregnanolone content and its synthase expression levels in the olfactory bulb. These results suggest that YKSCH treatment improved social isolation stress-induced insomnia via the GABAergic pathway and that the mechanism of action of YKSCH is partly due to improvement of allopregnanolone levels of expression.

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Section: Discussionmentioning

confidence: 75%

“…This is a Japanese language translation/reprint of 不眠モデルマウスにする抑肝散加陳皮半夏の果 originally published in phil 漢方 (phil Kampo) 70, [26][27]2018…”

Section: Data Availability Statementmentioning

confidence: 99%

Yokukansankachimpihange Improves the Social Isolation-Induced Sleep Disruption and Allopregnanolone Reduction in Mice

Murata¹,

Li²,

Shinguchi³

et al. 2020

Front. Nutr.

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“…Sedative-hypnotics or anti-anxiety agents have also been shown to increase pentobarbital-induced sleep duration ( Ma et al ., 2008 ). Treatment with caffeine, however, suppresses the expression of GABAergic systems and results in sleep disturbances ( Mukhopadhyay and Poddar, 2000 ; Li et al ., 2004 ; Mabunga et al ., 2015 ). In this study, we demonstrate that administration of caffeine (50 mg/kg) causes significant sleep disruptions during the pentobarbital-induced sleep test.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, caffeine also induces several adverse behavioral effects, including convulsive activity, the promotion of wakefulness, and locomotor stimulation even at relatively low doses ( Garrett and Holtzman, 1994 ). Additionally, the acute or chronic intake of caffeine in order to improve daily performance is commonly associated with sleep disturbances and insomnia, as well as other side effects including cardiovascular problems ( Mabunga et al ., 2015 ). In particular, previous studies have shown that caffeine exerts an allosteric effect on the γ-aminobutyric acid (GABA) A receptors and that it may reduce GABA neurotransmitter levels in the central nervous system (CNS) ( Kardos and Blandl, 1994 ; Fredholm et al ., 1999 ).…”

Section: Introductionmentioning

confidence: 99%

Evodiamine Reduces Caffeine-Induced Sleep Disturbances and Excitation in Mice

Shim

Lee

Jang

2018

Biomol Ther (Seoul)

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Worldwide, caffeine is among the most commonly used stimulatory substances. Unfortunately, significant caffeine consumption is associated with several adverse effects, ranging from sleep disturbances (including insomnia) to cardiovascular problems. This study investigates whether treatment with the Evodia rutaecarpa aqueous extract (ERAE) from berries and its major molecular component, evodiamine, can reduce the adverse caffeine-induced sleep-related and excitation effects. We combined measurements from the pentobarbital-induced sleep test, the open field test, and the locomotor activity test in mice that had been dosed with caffeine. We found that ERAE and evodiamine administration reduced the degree of caffeine-induced sleep disruption during the sleep test. Additionally, we found that evodiamine significantly inhibits caffeine-induced excitation during the open field test, as well as decreasing hyperlocomotion in the locomotor activity test. Additional in vitro experiments showed that caffeine administration decreased the expression of γ-aminobutyric acid (GABA)A receptor subunits in the mouse hypothalamus. However, evodiamine treatment significantly reversed this expression reduction. Taken together, our results demonstrate that ERAE and its major compound, evodiamine, provide an excellent candidate for the treatment or prevention of caffeine-induced sleep disturbances and excitatory states, and that the mechanism of these beneficial effects acts, at least in part, through the GABAA-ergic system.

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“…Several phytochemicals that are obtained from rice germs have been extensively utilized in medications, health and functional foods, cosmetics and food additives that include GABA (Mabunga et al, 2015;Shizuka et al 2004;Yoto et al, 2012) and γ-oryzanol (Wilson et al, 2007). Further, the nutritional values of some of the bioactive constituents found in rice germ are enhanced following fermentation (McGovern et al, 2004), for instance, α-ethylglucoside contained in fermented rice germ, is reported to prevent ultraviolet Bmediated disorder of epidermal permeability barrier (Hirotsune et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Quality Characteristics and Antioxidant Potential of Rice-Germ Rice Processed with Different Heat Treatments

Myung-Gu¹,

Byong-Hee²,

Dhungana³

et al. 2020

ijSciences

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Rice germ is a part of the rice kernel, and has been a matter of wide interest for food scientists and nutritionists because of its nutraceutical properties. The objective of this study was to investigate the physical and sensory characteristics and antioxidant properties of rice containing rice germs that were exposed to different heat treatments for 20 or 30 min. The thermal treatments significantly influenced the moisture content, color, antioxidant potential, and sensory characteristics of the rice. The antioxidant potential measured through DPPH free radical scavenging potential and total polyphenol content of the autoclaved rice sample was significantly lower than the other samples. Also, acceptability of the autoclaved sample was decreased as compared to the other samples. This study showed that greater antioxidative potential with higher acceptability of rice-germ rice could be obtained by mixing rice and water (10°C) at a 60:90 ratio followed by heat treatment (100°C) for 30 min.

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Treatment of GABA from Fermented Rice Germ Ameliorates Caffeine-Induced Sleep Disturbance in Mice

Cited by 39 publications

References 45 publications

Yokukansankachimpihange Improves the Social Isolation-Induced Sleep Disruption and Allopregnanolone Reduction in Mice

Yokukansankachimpihange Improves the Social Isolation-Induced Sleep Disruption and Allopregnanolone Reduction in Mice

Evodiamine Reduces Caffeine-Induced Sleep Disturbances and Excitation in Mice

Quality Characteristics and Antioxidant Potential of Rice-Germ Rice Processed with Different Heat Treatments

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