Treatment of Gallbladder Carcinoma in Early Stage

Kakita, Akira; Takahashi, Tsuyoshi; Kambayashi, Masaaki; Tsuburaya, Toshihiko; Funaki, S.

doi:10.5833/jjgs.18.883

Cited by 2 publications

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“…The prognosis of m-cancers within the mucosa and mp-cancers within the muscularis is favorable. However, although in some cases of m-and mp-cancers death due to postoperative recurrence did not occur [3][4][5], a few deaths due to recurrence have been reported [6][7][8][9][10][11].…”

Section: Resultsmentioning

confidence: 99%

Clinicopathological Evaluation of Surgical Treatment for Early Gallbladder Cancer.

et al. 2001

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We evaluated the therapeutic principles for early gallbladder cancer based on clinicopathological characteristics and outcomes in 27 patients encountered at the Kurume University Hospital between January, 1975 and December, 1999. Concerning the depth of wall penetration, 15 patients had mucosal cancers (m-cancers), and 12 patients muscularis propria cancers(mpcancers). The gross patterns were Ip (pedunculated) in 16 patients, Is (sessile) in 3 patients, Ila (flat elevated) in 4 patients, and Ilb (flat) in 4 patients. The operative procedure used was cholecystectomy (C) in 12 patients, 4 of whom underwent lymph node dissection. Full-thickness cholecystectomy (FTC) was carried out in 3 patients, one of whom had lymph node dissection. Combination of C and gallbladder bed resection (GbBR) was performed in 7 patients, 6 of whom had lymph node dissection. Combination of C and bile duct resection (BDR), and lymph node dissection was performed in 1 patient. Combination of C and GbBR and BDR, and lymph node dissection was performed in 6 patients. All the patients who underwent lymph node dissection were negative for metastasis. Of the 27 patients, 2 underwent laparoscopic operation: one with m-cancer was 79 years old, and the other with mp-cancer 86 years old. In the m-cancers, no lymphatic, venous or perineural infiltration was observed. In contrast, in the mp-cancers, lymphatic and venous infiltration each were observed in 4 patients (33.3%), although no perineural infiltration was observed. A diagnosis of gallbladder cancer was made postoperatively in 6 patients, of whom 4 had the Ilb pattern and all were complicated by gallstone, indicating the difficulty of diagnosing the Ilb pattern. The 5-year survival rates for the m-and mp-cancers were as high as 90.9% and 80.8%, respectively. As a curative surgical technique for m-and mp-cancers, lymph node dissection should be performed in addition to FTC, GbBR, and BDR, in combination. When a postoperative histopathologic diagnosis of gallbladder cancer has been made, no second-look operation should be performed for m-cancers, but lymph node dissection of up to the second group should be performed for mp-cancers in a second-look operation.

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Section: Resultsmentioning

confidence: 99%

Clinicopathological Evaluation of Surgical Treatment for Early Gallbladder Cancer.

et al. 2001

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Synchronous Triple Early Cancers Occurring in the Stomach, Colon and Gallbladder

Tamura

Shinagawa

Funaki

2003

Asian Journal of Surgery

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We report an unusual case of synchronous triple early cancers of the stomach, gallbladder and sigmoid colon. The patient was a 70-year-old man. Gastrointestinal endoscopy at a medical check-up initially revealed early gastric cancer. A thorough preoperative investigation showed a gallbladder tumour and early colon cancer. Endoscopic mucosal resection was performed for the colon cancer. Microscopically, the specimen showed well-differentiated adenocarcinoma involving the submucosal layer. Distal partial gastrectomy (D1) and simple cholecystectomy with lymph node dissection were also performed. The histopathological diagnosis was well-differentiated adenocarcinoma in the stomach (T1, N0, M0; Stage IA) and poorly differentiated papillary adenocarcinoma (T1, N0, M0; Stage I) in the gallbladder. The patient was doing well with no evidence of recurrence 6 months after surgery.

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Treatment of Gallbladder Carcinoma in Early Stage

Cited by 2 publications

References 0 publications

Clinicopathological Evaluation of Surgical Treatment for Early Gallbladder Cancer.

Clinicopathological Evaluation of Surgical Treatment for Early Gallbladder Cancer.

Synchronous Triple Early Cancers Occurring in the Stomach, Colon and Gallbladder

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