Synchronous Triple Early Cancers Occurring in the Stomach, Colon and Gallbladder

Tamura, Masaya; Shinagawa, Makoto; Funaki, Y

doi:10.1016/s1015-9584(09)60216-5

Cited by 33 publications

(23 citation statements)

References 4 publications

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“…In the literature, only five cases were related worldwide since 2005 [1] . However, in the last years, multiple primary tumors have been more frequently documented due to the increase in life expectancy and the improvement of diagnosis techniques [1,7] . A Japanese study done by Horii et al evidenced that microsatellite instabilities were frequently observed in multiple primary neoplasms rather than in single neoplasms [2,8] .…”

Section: Discussionmentioning

confidence: 99%

“…The Warren and Gates criteria define synchronic tumors and can be applied if a second primary tumor falls into these criteria: (a) each tumor should represent a single form of malignancy; (b) each tumor has to be distinct from each other; and/or (c) the metastatic tumor should be excluded [1,7] .…”

Section: Discussionmentioning

confidence: 99%

“…This is unusual considering that colon cancers with second primary tumors in other segments of the colon are a common finding. The standard surgical treatment for multiple primary tumors is the curative resection of each individual tumor, when it is feasible [2,7] . The prognostic of multiple tumors can be independently defined by the stage of each tumor isolate [10] .…”

Section: Discussionmentioning

confidence: 99%

“…Although very uncommon, almost 40% of multiple primary tumors involving gallbladder cancer are associated to gastric cancer and 30% to colon cancer [7] . As mentioned, the association of rectal cancer and gallbladder cancer is rare and the management of each one must be tailored according to it clinical settings.…”

Section: Ishak G Et Al Gallbladder and Rectal Synchronous Adenocarcmentioning

confidence: 99%

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Gallbladder and Rectal Synchronous Adenocarcinoma: Case Report

Ishak

Montenegro

Moreira-Nunes³

et al. 2014

Journal of Gastroenterology and Hepatology Research

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Synchronous tumors in both the rectum and the gallbladder are extremely rare. This study reports a case of gallbladder and rectal synchronic tumors, histopathologically confirmed, and discusses the therapeutic strategies in managing multiple primary cancers. Patient files from the Patient Files and Statistical Department of the University Hospital João de Barros Barreto and review of English literature were analyzed. Data from a case of a 69-year-old female patient with compressive vaginal and anal pain, constipation, and hematochezia were reviewed. Rectal touch evidenced a vegetating and infiltrative tumoral lesion, and colonoscopy demonstrated an elevated, vegetating, and infiltrative lesion. The histopathological analyses confirmed a moderately differentiated adenocarcinoma. A preoperative computer tomography scan was negative for metastasis investigation and, as an incidental finding, demonstrated cholelithiasis. The histological evaluation of the surgical specimens demonstrated rectal cancer, gallbladder cancer, and also hepatic metastasis. Due to the presence of hepatic and rectal cancer metastases, the standard management of the gallbladder cancer was modified according to the general concept that radical treatment of synchronous tumors should be reserved to situations were all tumors can be treated curatively or can improve life expectancy. Primary gallbladder and rectal synchronous neoplasms are rare and the treatment must be specific to each tumor, following the guidelines of each cancer whenever feasible. In case of metastasis or advanced stages of the disease, the treatment strategies must consider the most advanced tumor and/or the worst prognosis, and aggressive procedures must be avoided when it is not possible to radically treat every synchronous tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Ishak G Et Al Gallbladder and Rectal Synchronous Adenocarcmentioning

confidence: 99%

See 2 more Smart Citations

Gallbladder and Rectal Synchronous Adenocarcinoma: Case Report

Ishak

Montenegro

Moreira-Nunes³

et al. 2014

Journal of Gastroenterology and Hepatology Research

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“…The tumor type, location, stage and progression, as well as the patient's general health status should be considered. The treatment of choice involves curative surgical resection of each cancer, followed by radiotherapy and chemotherapy (16)(17)(18). The prognosis should be determined independently as a function of the tumor stage and treatment results for each cancer.…”

Section: Discussionmentioning

confidence: 99%

Case report of concurrent primary malignancies of the breast and nasopharynx

Pan

Zhu

2012

Oncology Letters

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Abstract. The aim of this study was to report a case of concurrent primary malignancies of the breast and nasopharynx and discuss the potential relationship between Epstein-Barr virus (EBV) infection and breast cancer. A 39-year-old female presented with a palpable mass present for 1 year in her left breast. Immunohistochemical staining was performed and the results showed that the tumor cells were immunopositive for the estrogen receptor, progesterone receptor and p53 protein, and markedly positive for C-erb B2. In addition, 30% of the tumor cells were positive for the Ki-67 antigen. Blood test results revealed that EBV-CA-IgG was present and EBV-EA-IgG was reactivated. The patient was diagnosed with breast cancer (T1N0M0) and EBV infection. A mastectomy with axillary clearance was performed on the left breast. Histopathological examination provided evidence of invasive ductal adenocarcinoma. Further evaluation due to epistaxis following the breast surgery resulted in a diagnosis of nasopharyngeal carcinoma (T2N1M0). Histopathology showed a non-keratinizing undifferentiated carcinoma. The patient was treated with chemoradiotherapy for nasopharyngeal carcinoma. Twelve months following surgery and chemoradiotherapy the patient was assessed at the Cancer Hospital of Guangxi Medical University outpatient clinic and no evidence of relapse or metastasis was found. Thus, EBV infection may be involved in the pathogenesis of breast cancer, as observed in nasopharyngeal carcinoma. IntroductionThe mechanisms responsible for the appearance of multiple primary cancers remain unclear. Among the factors most frequently involved are genetic susceptibility, the immune system and intensive exposure to carcinogens, including chemical and biological carcinogens and radiation.Breast cancer is the most common neoplastic disease of women in the Western world. In developed countries, more than 200 cases are diagnosed annually per 100,000 women. The etiology and mechanisms of breast cancer are poorly understood. Well-known risk factors, including those that affect circulating sex hormones and genetic background can only explain approximately 50% of all breast cancer cases. Among the remaining 50% of cases, findings of numerous studies have suggested that Epstein-Barr virus (EBV) infection may be a causal factor (1-4).EBV is a ubiquitous γ herpes virus and infects 90% of the population. In the majority of individuals, the virus persists for life in the memory B-cell pool (5) with no adverse health consequences. The virus is essentially a B-lymphotropic agent and is associated with malignancies of B-cell origin, including Burkitt's lymphoma. However, epithelial cell infection clearly occurs in vivo, as EBV is also associated with malignancies of epithelial origin, such as nasopharyngeal carcinoma (NPC). In Burkitt's lymphoma and NPC, epidemiological and molecular virological data favor the role of the virus as a cofactor in tumor initiation and/or development. The involvement of EBV has been demonstrated by the findings of EBNA-1 express...

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