Treatment of genital herpes using olive leaf extract

Lorzadeh, Nahid; Kazemirad, Yasaman; Kazemirad, Nastran

doi:10.1002/ccr3.3723

Cited by 7 publications

(5 citation statements)

References 13 publications

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“…However, a slight inhibition of HSV-1 infection was detected in the post-treatment assay, in particular at the higher concentrations (Figure 6D). Altogether, these data are in agreement with those reported in previous studies on olive leaf extracts [10,12,20] but this is the first study investigating OFE antiviral activity.…”

Section: Antiviral Activity Of Ofe Extractsupporting

confidence: 92%

Natural Formulations Based on Olea europaea L. Fruit Extract for the Topical Treatment of HSV-1 Infections

Cometa¹,

Zannella

Busto

et al. 2022

Molecules

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In the present study, a hydroxytyrosol-rich Olea europaea L. fruit extract (OFE) was added to three thoroughly green formulations—hydrogel, oleogel, and cream—in order to evaluate their antiviral activity against HSV-1. The extract was characterized by different analytical techniques, i.e., FT-IR, XPS, and TGA. HPLC analyses were carried out to monitor the content and release of hydroxytyrosol in the prepared formulations. The total polyphenol content and antioxidant activity were investigated through Folin–Ciocâlteu’s reagent, DPPH, and ABTS assays. The ability of the three formulations to convey active principles to the skin was evaluated using a Franz cell, showing that the number of permeated polyphenols in the hydrogel (272.1 ± 1.8 GAE/g) was significantly higher than those in the oleogel and cream (174 ± 10 and 179.6 ± 2 GAE/g, respectively), even if a negligible amount of hydroxytyrosol crossed the membrane for all the formulations. The cell viability assay indicated that the OFE and the three formulations were not toxic to cultured Vero cells. The antiviral activity tests highlighted that the OFE had a strong inhibitory effect against HSV-1 with a 50% inhibitory concentration (IC50) at 25 µg/mL, interfering directly with the viral particles. Among the three formulations, the hydrogel exhibited the highest antiviral activity also against the acyclovir-resistant strain.

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Section: Antiviral Activity Of Ofe Extractsupporting

confidence: 92%

Natural Formulations Based on Olea europaea L. Fruit Extract for the Topical Treatment of HSV-1 Infections

Cometa¹,

Zannella

Busto

et al. 2022

Molecules

View full text Add to dashboard Cite

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“…OLE polyphenols have shown antiviral activities [ 76 , 77 , 82 , 83 , 84 , 85 , 86 , 87 ] and antiprotozoal activities, including both antitrypanosomal and antileishmanial activity; thus, it is safe to suggest that Cobrançosa’s leaf sprouts and elementary leaves are both viable sources of TPC to study in the treatment of CVD, IR promoting euglycemia, and hypertension but, also to boost immune action against bacterial, viral, and protozoal infections.…”

Section: Discussionmentioning

confidence: 99%

Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea

Melo

Oliveira

Chéu

et al. 2023

Plants

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Olea europaea L. folium merits further exploration of the potential of its substrates for therapeutic supplements. Quantitative and qualitative analyses were conducted on samples of Madural, Verdeal, and Cobrançosa elementary leaves and leaf sprouts (mamões) collected in the region of Valpaços, Portugal. Organic analysis assessed the moisture content, total carbohydrates, ash, protein, and fat contents, total phenolic content (TPC), vitamin E, and fatty acid (FA) profiles. Moisture content was determined through infrared hygrometry and TPC was determined by a spectrophotometric method. Concerning organic analysis, all leaf samples showed similar moisture content, though Cobrançosa’s leaf sprouts and Verdeal’s elementary leaves had slightly lower contents. Meanwhile, these cultivars also showed a higher TPC, α-tocopherol isomer, and fatty acid composition (FAC). FAC in all samples exhibited higher contents of PUFA and SFA than MUFA, with a predominance of linolenic and palmitic acids. Organic analyses of Cobrançosa’s leaf sprouts and Verdeal’s elementary leaf extracts allow for the prediction of adequate physiological properties regarding neuroinflammatory, neurobehavioral, metabolic, cardiovascular, osteo-degenerative, anti-ageing, pulmonary, and immunological defense disorders. These physiological changes observed in our preliminary in silico studies suggest an excellent nutraceutical, which should be borne in mind during severe pandemic situations.

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“…Since it is well known that biophenolic compounds from olive leaf extracts may exert beneficial properties for human health, a large amount of bioactive phenols is consequently squandered in this way. According to the literature, the pharmacological properties of biophenols include antioxidant [ 6 ], anti-inflammatory [ 7 , 8 ], antimicrobial [ 9 ], antiviral [ 10 ] and anti-carcinogenic activities [ 11 ], as well as beneficial cardiovascular effects [ 12 ]. These effects are attributed strictly to the presence of a range of compounds primarily dominated by phenolic acids (ferulic, vanillic, and caffeic acid), phenolic alcohols (tyrosol and hydroxytyrosol), flavonoids (luteolin-7- O -glucoside, apigenin-7- O -glucoside, rutin, luteolin-4′- O -glucoside, apigenin, and luteolin), hydroxycinnamic acid derivatives (verbascoside), and secoiridoids (oleuropein) [ 3 , 11 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Biophenolic Profile Modulations in Olive Tissues as Affected by Manganese Nutrition

Vidović

Pasković

Lukić

et al. 2021

Plants

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Manganese (Mn) is an essential element that intervenes in several plant metabolic processes. The olive tree, and its fruits and leaves, are known as a source of nutraceuticals since they are rich in biophenols. However, there is still a serious lack of data about biophenolic distribution in olive stems and roots under Mn fertilisation. In this context, our study aimed to examine the effects of Mn fertilisation on the biophenolic profile in the leaves, stems, and roots of the ‘Istarska bjelica’ olive cultivar. The experiment was set up in a greenhouse, during a period of five months, as a random block design consisting of three treatments with varying Mn concentrations in full-strength Hoagland’s nutrient solution (0.2 µM Mn, 12 µM Mn, and 24 µM Mn). The obtained results indicate that the amount of Mn in the examined olive plant tissues was significantly higher under 12 µM Mn and 24 µM Mn treatments compared to that of the 0.2 µM Mn treatment. While the concentration of biophenols varied in roots depending on the compound in question, a strong positive impact of the increased Mn concentration in nutrient solution (12 µM Mn and 24 µM Mn) on the concentrations of the main biophenolic compounds was observed in stems. The concentration of oleuropein in leaves almost doubled at 24 µM Mn, with the highest Mn concentration, as compared to the 0.2 µM Mn treatment. The obtained results led to the conclusion that the supply of Mn could enhance the concentration of some biologically active compounds in olives grown hydroponically, implying a critical need for further investigation of Mn fertilisation practices in the conventional olive farming system.

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Treatment of genital herpes using olive leaf extract

Cited by 7 publications

References 13 publications

Natural Formulations Based on Olea europaea L. Fruit Extract for the Topical Treatment of HSV-1 Infections

Natural Formulations Based on Olea europaea L. Fruit Extract for the Topical Treatment of HSV-1 Infections

Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea

Biophenolic Profile Modulations in Olive Tissues as Affected by Manganese Nutrition

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