Treatment of hay fever with loratadine ‐ a new non‐sedating antihistamine

Irander, Kristina; Ödkvist, Lars; Ohlander, B

doi:10.1111/j.1398-9995.1990.tb00463.x

Cited by 15 publications

(4 citation statements)

References 15 publications

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“…'5 • 16 Histamine is also an important mediator in patients with allergic rhinitis as shown by the effect of HI-antihistamine drug such as loratadine. 17 In conclusion, we found that the nasal passage patency in allergic guinea pigs with the use of AR was reduced by antigen challenge. The effects of antigen challenge were blocked by pretreatment with ketotifen.…”

Section: Discussionmentioning

confidence: 60%

Acoustic Rhinometry Evaluation of Nasal Response to Histamine and Antigen in Guinea Pigs

Ohkawa

Ukai

Miyahara

et al. 1999

American Journal of Rhinology

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The effects of antigen and histamine on the changes of nasal passage patency in 112 guinea pigs with or without allergic rhinitis were evaluated by acoustic rhinometry. The percent change of volume from the nostril to 2 cm into the nasal cavity showed significant reduction of 31.10 +/- 4.11% at 10 minutes and 31.10 +/- 4.11% at 30 minutes after antigen challenge in sensitized guinea pigs. The pretreatment with ketotifen, an H1-histamine receptor antagonist as well as mast cell stabilizing drug, blocked dose-dependently the effects of antigen on those changes in volume. Furthermore, instillation of 10(4) micrograms/mL histamine reduced significantly nasal passage patency to 33.77 +/- 4.63% at 10 minutes and 42.76 +/- 3.32% at 30 minutes after challenge compared with that before challenge and ketotifen inhibited the effects of histamine, which indicated that histamine is an important mediator of allergic upper airway responses in guinea pigs. These results show that acoustic rhinometry is a useful technique to assess the nasal blockade in allergic guinea pigs.

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Section: Discussionmentioning

confidence: 60%

Acoustic Rhinometry Evaluation of Nasal Response to Histamine and Antigen in Guinea Pigs

Ohkawa

Ukai

Miyahara

et al. 1999

American Journal of Rhinology

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“…Cetirizine and loratadine are two secondgeneration antihistamines widely used to treat allergic rhinitis and urticaria (6)(7)(8)(9)(10)(11)(12)(13). Peak plasma concentration occurs about 1 h after intake for both antihistamines (14,15).…”

mentioning

confidence: 99%

Onset of action in the nasal antihistaminic effect of cetirizine and loratadine in patients with allergic rhinitis

Frossard

Lacronique

Mélac

et al. 1997

Allergy

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Several studies have compared the cutaneous efficacy of cetirizine and loratadine and their onset of action. We assessed the nasal effect of these two antihistamines in a randomized, double-blind, crossover, placebo-controlled trial in order to compare objectively their efficacy and onset of action in the noses of patients with allergic rhinitis. Nasal challenge was performed by nebulization of increasing doubling doses of histamine (0, 0.04-1.28 mg/nostril) in 12 patients (eight men, four women, aged 22-39 years). Nasal airway resistance (NAR) was measured by posterior rhinomanometry either 1.5 h or 4 h after intake of cetirizine (10 mg), loratadine (10 mg), or placebo. Baseline NAR was identical between all study days (2.60-2.88 cmH2O.l-1.s). One and a half hours after intake, the increase in NAR induced by histamine was significantly reduced by both cetirizine and loratadine in contrast to placebo. However, with cetirizine the nasal obstruction was significantly lower than with loratadine (P < 0.05). Four hours after intake, a similar inhibition of the nasal obstruction caused by histamine was observed with both cetirizine and loratadine (P < 0.05). In conclusion, this study found cetirizine and loratadine to have similar nasal efficacy at therapeutic dosage 4 h after intake, whereas cetirizine was more effective than loratadine 1.5 h after intake. In agreement with the results observed in the skin, our study suggests a more rapid onset of action of cetirizine in the nose in allergic rhinitis.

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“…These findings suggest antihistamines may cause weight gain. However, a previous study showed no weight gain with second generation antihistamines loratadine and clemastine in patients with hay fever (Irander et al 1990). Loratadine dose does not seem to have an impact on weight gain as demonstrated by our results.…”

Section: The Effect Of Antihistamine On Weightmentioning

confidence: 94%

Chronic Spontaneous Urticaria in Adult Patients: Evaluating the Effect of Loratadine on Weight and Metabolic Syndrome

KUAN¹,

JAMIL

ARUMUGAM³

et al. 2022

JSKM

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Antihistamine is standard chronic spontaneous urticaria (CSU) therapy. Weight gain is a side effect of concern as prolonged high dose therapy is common. We investigated the effects of 12-weeks loratadine therapy on weight, appetite and parameters of metabolic syndrome (MetS). A cohort study was performed involving CSU patients aged ≥18 years. Patients with diseases or on drugs affecting weight or appetite were excluded. CSU was treated according to standard management. Weight, height, waist circumference (WC), body mass index (BMI) and blood pressure (BP), Urticaria Activity Score 7 (UAS7), Dermatology Life Quality Index (DLQI), hunger and satiety questionnaire, fasting blood sugar (FBS) and fasting lipid profile (FLP) were obtained at baseline, week 6 and week 12. Loratadine cumulative dose were determined. Thirteen (33.33 %) males and 26 (66.67 %) females aged 33.00 (12.00) years participated. Median weight was 62.55 (18.30) kg, BMI 24.60 (6.80) kg/m2, 13(33.33%) patients had normal weight, 12 (30.77%) overweight, 11 (28.21%) obese and 3 (7.69%) underweight. Significant weight gain was observed at week 6, 67.56 ± 16.14 kg vs 68.16 ± 16.95 kg, p < 0.05 and 67.56 ± 16.14 kg vs 64.73 ± 14.60 kg, p = 0.04 at week 12. Changes in BMI, WC, BP, FBS and FLP were insignificant. Three patients developed MetS. Hunger and satiety scores were unaffected. Loratadine induced weight gain despite no effects on appetite. Weight should be monitored in patients on long term loratadine therapy. Keywords: Urticaria; loratadine; weight gain; metabolic syndrome; appetite

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Treatment of hay fever with loratadine ‐ a new non‐sedating antihistamine

Cited by 15 publications

References 15 publications

Acoustic Rhinometry Evaluation of Nasal Response to Histamine and Antigen in Guinea Pigs

Acoustic Rhinometry Evaluation of Nasal Response to Histamine and Antigen in Guinea Pigs

Onset of action in the nasal antihistaminic effect of cetirizine and loratadine in patients with allergic rhinitis

Chronic Spontaneous Urticaria in Adult Patients: Evaluating the Effect of Loratadine on Weight and Metabolic Syndrome

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