Treatment of Heart Failure in Patients With Diabetes Mellitus

Біловол, Олександр Миколайович; Kniazkova, I. I.; Bohun, M. V.; Kuzmіnova, N. V.; Osovska, Natalia Y

doi:10.26724/2079-8334-2020-1-71-18-22

Cited by 1 publication

(1 citation statement)

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“…Changes in the parameters of endothelial function in obese animals, found during the study, reflect a high risk of developing vascular disorders, because a significant increase in ET-1 can be a consequence of the inflammatory process, the progression of oxidative stress, excessive production of cytokines and stimulation of the generation of free radicals. Under the conditions of excessive body weight, adipose tissue and its adipokine are important for the development of endothelial dysfunction, because under such conditions, inflammatory processes are activated, which directly or indirectly depend on the substances it synthesizes [26,27]. Thus, an increased amount of reactive oxygen species causes cell damage and death, and oxidative stress increases the permeability of the vascular endothelium and leads to the adhesion of leukocytes [28].…”

Section: Discussionmentioning

confidence: 99%

Changes of endothelial function and oxidant status in insulin resistance and obesity under the conditions of iodine deficiency

Todoriv

Voronych-Semchenko

Didushko

2023

Mìžnarodnij endokrinologìčnij žurnal

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Background. The topicality of the theme is due to the significant prevalence of cardiovascular diseases and an increase in costs for medical care, the high risk of disability, which characterizes the medical and social component of the problem. Pathological changes can be a manifestation not only of a cardiovascular disorder, but also develop as a result of other diseases, including diabetes mellitus, obesity, and thyroid pathology. One of the main mechanisms of morbidity and mortality is macrovascular complications that can occur in endothelial dysfunction and oxidative stress. The purpose of the research is to study the peculiarities of changes in the parameters of the endothelial system and oxidant status in animals with insulin resistance and obesity under conditions of adequate iodine supply and iodine deficiency. Materials and methods. Study included 75 sexually mature rats having received a high-carbohydrate, high-fat diet under conditions of adequate and limited iodine supply, followed by analysis of markers of carbohydrate metabolism, thyroid status, indices of endothelial function, lipid peroxidation and antioxidant protection. Results. The development of insulin resistance and obesity in a diet loaded with fructose and fats is accompanied by the development of endothelial dysfunction: in the blood serum, the level of endothelin-1 increases and inducible NO-synthase (iNO-synthase) is activated, in the myocardium, the activity of iNO-synthase increases compared to the data in animals who received a standard diet. The development of oxidative stress in experimental animals characterizes an increase in the content of diene conjugates and thiobarbituric acid-reactive substances in blood serum and myocardium against the background of inhibition of serum antioxidant enzymes (catalase, superoxide dismutase, ceruloplasmin, glutathione peroxidase, glutathione reductase). The degree of endothelial dysfunction and the intensity of lipoperoxidation increase with hypothyroid dysfunction against the background of iodine deficiency. Conclusions. Metabolic disorders under the conditions of insulin resistance and obesity are characterized by the development of endothelial dysfunction and oxidative stress, which are the predictors of the development of cardiovascular risks. Their intensity depends on carbohydrate and thyroid homeostasis.

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Section: Discussionmentioning

confidence: 99%