Treatment of Helicobacter pylori Reduces the Rate of Rebleeding in Peptic Ulcer Disease

Graham, David Y.; Hepps, Kenneth S.; Ramirez, Francisco C.; Lew, Ginger M.; Saeed, Zahid A.

doi:10.3109/00365529309098288

Cited by 237 publications

(116 citation statements)

References 19 publications

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“…14 Shipnen et al 1992, Grahm et al 1991 reported that H. pylori infection more common in lower socioeconomic status and author have reported similar results in this study amongst patients with perforation H. pylori infection is the same across the socioeconomic status (50% for lower socioeconomic group, 56% in the rest). 15,16 The stool antigen test for detection of H. pylori was carried out in 20 out of 75 patients with perforated peptic ulcer and it was found to be negative for H. pylori for all the 20 patients. The sensitivity of stool antigen test in simple ulcer as reported in literature is in range of 88-100%.…”

Section: Resultsmentioning

confidence: 99%

The prevalence of Helicobacter pylori in perforated peptic ulcer disease

Rehmani

Pathak

2018

Int Surg J

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Background: Although the role of Helicobacter pylori infection in noncomplicated peptic ulcer disease has been definitively established, the precise relationship between the organism and ulcer complications is doubtful. Recurrent ulcer disease after peptic ulcer perforation mainly occurs in patients with H. pylori infection, which suggests that the microorganism plays an important role in this complication.Methods: This observational study was conducted in the Department of General Surgery, Himalayan Institute of Medical Sciences (HIMS), Swami Ram Nagar, Dehradun, over a period of January 2013 to December 2013 and included 75 subjects who underwent exploratory laparotomy for peptic ulcer perforation. The tests used for the diagnosis of H. pylori are mucosal biopsy at the time of surgery, Rapid urease test (RUT), Stool antigen test.Results: In this study, H. pylori infection was found to be present in 61% of these patients as detected by biopsy. There were 66 males and 9 females. Infection with H. pylori is almost universal in patients aged more than 70 years.Conclusions: In the Indian context patients presenting with perforation should be tested for infection with H. pylori utilizing a gastric antral mucosal biopsy taken at the time of operation for histological analysis and eradication therapy should be advised to all those who are found positive.

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Section: Resultsmentioning

confidence: 99%

The prevalence of Helicobacter pylori in perforated peptic ulcer disease

Rehmani

Pathak

2018

Int Surg J

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“…Exaggerated mealstimulated gastrin release was shown to be related to H. pylori infection and reversed following cure of the infection. 27,28 The inability to demonstrate a relationship between gastrin secretion or acid secretion and H. pylori infection, and the ®nding that the parietal cell mass did not reliably fall following a cure of the infection, eliminated the hypothesis that the gastrin was responsible, either directly or indirectly, for the trophic eect seen in duodenal ulcer disease. 29±32 Overall, these observations provided the basic knowledge of studies required in order to understand how to evaluate H. pylori-related perturbations in gastric function (Table 2).…”

Section: Secretionsmentioning

confidence: 99%

Pathogenesis of duodenal ulcer disease: the rest of the story

Dore

Graham

2000

Best Practice & Research Clinical Gastroenterology

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“…15 About 1 in 10 duodenal ulcers bleed for reasons that remain unclear, but of critical importance is the fact that eradication of H. pylori dramatically reduces the occurrence of rebleeding from both duodenal and gastric ulcers. 16 Curiously, a similar beneficial impact has not been demonstrated for H. pylori eradication in the management of peptic ulcer perforation. 17 The prevalence of H. pylori-negative peptic ulcer disease appears to be on the increase.…”

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confidence: 99%