Treatment of high-risk gestational trophoblastic neoplasia with weekly high-dose methotrexate–etoposide

Han, Sileny N.; Amant, Frédéric; Leunen, Karin; Devi, U. K.; Neven, Patrick; Berteloot, Patrick; Vergote, Ignace

doi:10.1016/j.ygyno.2012.06.014

Cited by 9 publications

(5 citation statements)

References 26 publications

(36 reference statements)

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“…In general, both therapies were highly effective and well tolerated; however, the authors suggested a slight therapeutic advantage of ACT chemotherapy over the MTX one. Two therapies applied in patients with high-risk GTN are described in the work of Han et al [238]. The therapies were conducted using the following regimens: HDMTX-etoposide and etoposide-cisplatin in combination with etoposide-MTX-dactinomycin (EP-EMA).…”

Section: Methotrexate-based Therapy Of Gestational Trophoblastic Diseasementioning

confidence: 99%

Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers

Koźmiński

Halik

Chesori

et al. 2020

IJMS

224

120

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Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune diseases. In this paper, we take an overview of the present state of knowledge with regards to complex mechanisms of methotrexate action and its applications as immunosuppressive drug or chemotherapeutic agent in oncological combination therapy. In addition, the issue of the potential benefits of methotrexate in the development of neurological disorders in Alzheimer’s disease or myasthenia gravis will be discussed.

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Section: Methotrexate-based Therapy Of Gestational Trophoblastic Diseasementioning

confidence: 99%

Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers

Koźmiński

Halik

Chesori

et al. 2020

IJMS

224

120

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“…Complete remission of choriocarcinoma achieved by chemotherapy was reported several times after our study [3][4][5][6], while no active prevention of choriocarcinoma with MTX chemotherapy has been found in recent reports after our study, though it is an important obligation of researchers for choriocarcinoma.…”

Section: Discussionmentioning

confidence: 59%

Trophoblast Biology, Biochemical Therapy and Prevention of Choriocarcinoma

Maeda¹

2016

Clin Med Biochemistry

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Biochemical tumor marker was human chorionic gonadotropin (hCG) produced by choriocarcinoma itself, which was used to determine the complete remission of the carcinoma, which was treated by primary systemic methotrexate (MTX) therapy. Also, hCG was the marker of positive pregnancy test in the MTX prevention of choriocarcinoma. It will be important to use biochemical marker produced by the subject in the chemotherapy of malignant tumor.

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“…Embolization is the preferred choice of treatment to control bleeding in liver metastasis (17). Metastases to the brain have a poorer prognosis (18). Vugrin et al reported 5 patients who died with median survival of only 1 month despite treatment with multi-agent chemotherapy (19).…”

Section: Discussionmentioning

confidence: 99%

A rare case of metastatic choriocarcinoma to multiple organs causing intractable bleeding.

Tan¹,

Tay²,

Chan³

2016

Cancer Res Front

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Treatment of high-risk gestational trophoblastic neoplasia with weekly high-dose methotrexate–etoposide

Cited by 9 publications

References 26 publications

Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers

Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers

Trophoblast Biology, Biochemical Therapy and Prevention of Choriocarcinoma

A rare case of metastatic choriocarcinoma to multiple organs causing intractable bleeding.

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