1986
DOI: 10.1007/bf00613522
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Treatment of hydatid disease with high oral doses of mebendazole

Abstract: Plasma mebendazole levels were analysed retrospectively in patients treated for inoperable infections with Echinococcus multilocularis or granulosus. In 10 patients receiving mebendazole at 4 dose levels there was no relation between dose and plasma concentration. In 17 patients followed on the same dose for more than 18 months, the plasma levels varied with individual coefficients of variation ranging from 27 to 72%. The data reveal the limitations of single measurements of plasma mebendazole and emphasize th… Show more

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Cited by 54 publications
(18 citation statements)
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“…Only 10% of plasma levels can be found in the hydatid fluid. They cause blockage of glucose absorption of the scolices, degeneration in mi crotubules and cellular autolysis [10][11][12][13][14],…”
Section: Introductionmentioning
confidence: 99%
“…Only 10% of plasma levels can be found in the hydatid fluid. They cause blockage of glucose absorption of the scolices, degeneration in mi crotubules and cellular autolysis [10][11][12][13][14],…”
Section: Introductionmentioning
confidence: 99%
“…After duplicate articles were removed, titles and abstracts of articles were reviewed by two authors, producing 35 articles , of which 17 were included in the review [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Eighteen articles were excluded for the following reasons: eight articles used animals [26][27][28][29][30][31][32][33]; two articles contained only in vitro data [34,35]; two articles did not contain any pharmacokinetic data of either albendazole or mebendazole [36,37]; two articles only contained data on drug-food interactions [38,39]; and four articles did not contain data on any drug interactions with either albendazole or mebendazole [40][41][42][43].…”
Section: Search Resultsmentioning
confidence: 99%
“…The inhibitory effect of cimetidine was more clearly demonstrated by Luder et al [24] in that patients taking [16.6] cimetidine with mebendazole exhibited higher plasma concentrations of mebendazole. However, it is important to note that this increase in plasma mebendazole concentration was believed to be too small to be of clinical relevance [24].…”
Section: Cimetidinementioning
confidence: 91%
See 1 more Smart Citation
“…In this report, it is stated that patients with an intact germi native membrane, and living scolices in the cystic liquid as shown by vital dye staining and/or cystic development in BALB/C mice after intraperitoneal injection of the cystic fluid, have mebendazole levels less than 47.6 ng/ml in plasma and 4.4 ng/ml in the cys tic fluid. Also, Luder et al [21] pointed out that when it is given in doses of 29-100 mg/ kg, in the 4th hour the serum concentration level was 102-540 nmol/1. Likewise, Bekhti and Pirotte [18] have observed that 2 h after the daily dosage of 3 x 1.5 g mebendazole was given, the serum level was 55 ng/ml on average.…”
Section: Discussionmentioning
confidence: 99%