Treatment of hypertensive emergencies with oral labetalol.

Abstract

the right leg at age 52 and later of left leg. No history of DVT; no family history of leg ulcers. Left inguinal herniorrhaphy at age 45. Case 2-Born 1915, single, height 1-8 m, weight 95 3 kg. Ulceration of left leg at age 39. Mild eczema of the right leg. No history of DVT. Mother and maternal aunt had leg ulcers. Case 3-Born 1944, single, height 1 8 m, weight 93-9 kg. Ulceration of the right leg at age 29. Four years previously he injured the right foot. This was followed by DVT and pulmonary embolus. Case 4-Born 1918, married, height 1 77 m, weight 92 1 kg. At age 53 ulceration of the left leg developed and later eczema of the right leg. Thrombophlebitis of the left leg occurred before ulceration. History of varicose veins in his mother's family. Case 5-Born 1924, height 1-77 m. Ulceration of right leg at age 40. Operation for varicose veins at 27. No history of phlebitis or thrombosis. His mother had varicose veins and his maternal grandmother leg ulcers. Two brothers had no leg trouble. Case 6-Born 1907, very tall, weight 76-9 kg. Ulceration of legs present with a generalised rash at age 44. Subsequently he had eczema of both legs and a small ulcer on the medial aspect of the left ankle.

Labetalol in the treatment of patients with hypertension and renal function impairment.

“…More recently a 'single oral dose of 300-400 mg labetalol has been found to be effective in rapidly controlling severe hypertension. Similar results have been reported by Ghose et al (1978).…”

Monotherapy with labetalol for hypertensive patients with normal and impaired renal function.

“…It is interesting to note that the speed of onset following oral administration is also rapid. A significant hypotensive response is seen between 1.5-2 h, and Ghose et al (1978) have suggested that the oral preparation is quite acceptable for the treatment of most hypertensive emergencies. This rapid reduction in BP seen following oral administration is almost certainly due to the a-adrenoceptor-blocking component, as we have shown along with other workers that both the selective and non-selective B-adrenoceptor-blocking drugs will only produce a significant reduction in systolic and diastolic BPs after the lapse of at least 12-24 hours.…”

Pharmacokinetics and pharmacodynamic studies of labetalol in hypertensive subjects.

“…After the administration of the radiolabelled drug, high levels of radioactivity have been found in liver, lung and kidney (Martin et al, 1976 (Louis et al, 1978a;Louis et al, 1978b) and in most clinical situations the drug is best given in divided doses. Unlike other ,B-adrenoceptor-blocking drugs, labetalol causes a significant fall in BP following single doses of the drug given either intravenously of orally (Koch 1976;Ghose et al, 1978). After the intravenous dose there was a significant effect on both systolic and diastolic BPs within 5 minutes.…”