Femoral facial syndrome is a rare clinical entity characterized by unilateral or bilateral femoral hypoplasia along with various malformations of face. Only few cases have been detected by antenatal ultrasonography so far. We present the case of one-day-old, male child, born to a primi gravida with oligohydramnios and severe growth restriction. The child had unusual facies with posterior cleft palate, non-communicating hydrocephalus and complete absences of left femur, hypoplasia of right femur, bilateral club foot and bilateral undescended testis.

the right leg at age 52 and later of left leg. No history of DVT; no family history of leg ulcers. Left inguinal herniorrhaphy at age 45. Case 2-Born 1915, single, height 1-8 m, weight 95 3 kg. Ulceration of left leg at age 39. Mild eczema of the right leg. No history of DVT. Mother and maternal aunt had leg ulcers. Case 3-Born 1944, single, height 1 8 m, weight 93-9 kg. Ulceration of the right leg at age 29. Four years previously he injured the right foot. This was followed by DVT and pulmonary embolus. Case 4-Born 1918, married, height 1 77 m, weight 92 1 kg. At age 53 ulceration of the left leg developed and later eczema of the right leg. Thrombophlebitis of the left leg occurred before ulceration. History of varicose veins in his mother's family. Case 5-Born 1924, height 1-77 m. Ulceration of right leg at age 40. Operation for varicose veins at 27. No history of phlebitis or thrombosis. His mother had varicose veins and his maternal grandmother leg ulcers. Two brothers had no leg trouble. Case 6-Born 1907, very tall, weight 76-9 kg. Ulceration of legs present with a generalised rash at age 44. Subsequently he had eczema of both legs and a small ulcer on the medial aspect of the left ankle.

Introduction: Osteoarthritis (OA) is commonly prevalent disorder seen in Indian population. Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) are used as primary drugs for its symptomatic treatment. However, its use is limited by its long-term adverse effects. Many clinical studies have shown that diacerein reduces clinical symptoms of OA. Aim: To evaluate whether diacerein has beneficial anti-arthritic property when used prophylactically in Freund’s Complete Adjuvant (FCA) induced arthritis in rats. Materials and Methods: An experimental study was conducted over a period of about two months in the Department of Pharmacology, SCBMC, Cuttack. Thirty albino rats of Wistar strain was divided into 5 groups with 6 animals in each group. The basal body weight and the hind paw volumes of both right and left paw of all the animals was noted in day 0 and then on 4th, 8th, 14th and 21st day. Arthritis was induced in all animals by injecting FCA on day 0 into the plantar surface of right hind paw. Normal saline, diclofenac 5 mg/kg, three doses of diacerein (50 mg/kg, 100 mg/kg, 200 mg/kg), was administered orally once daily to groups I, II, III, IV and V respectively. Paw volumes and body weight was measured for arthritic parameters. On day 22 radiological and histopathologic evaluation was done. Results: Maximum inhibition of Freund’s adjuvant induced arthritic paw volume was on the 21st day with 100 mg/kg of diacerein and with diclofenac 5 mg/kg was from 8th to 14th day. There was a decrease in body weight due to freund’s adjuvant in normal saline group from 4th to 21st day, still greater decline with diclofenac 5 mg/kg group, but in diacerein treated group there was an increase in body weight from 4th to 21st day in all the three doses. Radiologically and histopathology maximum benefit was noted with 100 mg/kg of diacerein. Conclusion: Three weeks treatment of oral diacerein can significantly inhibit arthritic swelling of the injected paw at all the 3 doses in adjuvant induced arthritis model in rats and can be a promising disease modifying drug for OA.

Fixed dose combinations (FDC) enhance the efficacy of individual drugs, decrease the chances of drug resistance, improve patient compliance and also decrease the pill burden on the patients. Irrational prescribing of FDCs is a major health concern. Aims & Objectives: To study the utilisation pattern of fixed dose drug combinations used in paediatric patients Materials and Methods: The study was conducted during September 2014 to October 2015 in paediatric patients visiting the OPD of a tertiary care teaching hospital of eastern India. After obtaining informed consent, prescriptions were collected from OPD every Thursday from 10 A.M. to 1P.M. and data analyzed and evaluated as per W. H. O. prescribing indicators. Results: 1380 prescriptions were collected and analysed. It was found that most FDCs were antibiotics, multivitamins formulations, analgesic-antipyretic combinations, cough and cold preparations. Conclusion: There is an increasing trend towards prescribing FDCs. Many of the FDCs are not included in the WHO Model list of essential medicines and the National List of Essential Medicines. Assessment of prescribing pattern in medical care facilities helps in identifying problems regarding rational use and to propose interventions.

Background: Neonatal sepsis remains a leading cause of neonatal mortality and morbidity, diagnosis of which remains difficult due to variable presentations. With the increasing threat of antimicrobial resistance, it is important to identify perinatal risk factors which are associated with higher incidence of definite sepsis, to initiate empirical antibiotics, while awaiting blood culture reports.Methods: This was hospital based cross-sectional study done in SVPPGIP, Cuttack, Odisha during January 2019 to April 2019, enrolling all neonates  ≥37 weeks gestation and aged less than 72 hours, with suspected early onset sepsis. Neonates with TORCH infections, congenital anomalies, syndromic baby or with surgical conditions were excluded. After obtaining informed consent, blood culture was sent for all and their perinatal risk factors noted. Blood culture positive newborns were considered to have definite sepsis. Data was analysed with Chi-square test and percentages, using SPSS 18.Results: Among the 200 cases, incidence of definite sepsis was 26%. The most common risk factor was low birth weight and birth asphyxia. Majority (67%) had single or lesser risk factor and number of risk factors was significantly associated with definite sepsis. A significant association was seen between blood culture positivity with low birth weight (p=0.003), foul smelling liquor (p= 0.025), birth asphyxia (p 0.018) and premature rupture of membranes (p= 0.016). The combination of maternal fever and unclean vaginal examination was also significantly associated with the same.Conclusions: Protocols for initiating empiric antibiotics need to be formulated, taking into account the significant risk factors, in resource limited settings, to avoid resource and time wastage.