2000
DOI: 10.1038/sj.ijo.0801440
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Treatment of hypertriglyceridemia by two diets rich either in unsaturated fatty acids or in carbohydrates: effects on lipoprotein subclasses, lipolytic enzymes, lipid transfer proteins, insulin and leptin

Abstract: BACKGROUND: There is lack of agreement on which dietary regimen is most suitable for treatment of hypertriglyceridemia, especially if high triglyceride concentrations are not due to obesity or alcohol abuse. We compared the effects on blood lipids of a diet high in total and unsaturated fat with a low-fat diet in patients with triglyceride concentrations of b 2.3 mmolal. METHODS: Nineteen non-obese male outpatients with triglycerides ranging from 2.30 to 9.94 mmolal received two consecutive diets for 3 weeks e… Show more

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Cited by 41 publications
(26 citation statements)
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“…More recently, the majority of studies performed have shown that high CHO diets induce a significant increase in fasting TG concentrations, by about 20%, compared to high-fat diets (Riccardi and Rivellese, 1991;Garg, 1998;Pieke et al, 2000;Mittendorfer and Labros, 2001;Hellerstein, 2002). This is evident also after only moderate changes in the proportion of CHO and fat, which may be considered acceptable from a clinical point of view.…”
Section: Introductionmentioning
confidence: 77%
See 1 more Smart Citation
“…More recently, the majority of studies performed have shown that high CHO diets induce a significant increase in fasting TG concentrations, by about 20%, compared to high-fat diets (Riccardi and Rivellese, 1991;Garg, 1998;Pieke et al, 2000;Mittendorfer and Labros, 2001;Hellerstein, 2002). This is evident also after only moderate changes in the proportion of CHO and fat, which may be considered acceptable from a clinical point of view.…”
Section: Introductionmentioning
confidence: 77%
“…Although this concordance of results is true for fasting TG concentrations, less is known about the effects of dietary CHO and fat on postprandial TG. The few data available on this topic have been obtained especially in acute experiments and remain substantially controversial, with some studies showing an increase after high CHO diets or high-fat meals and others just the opposite, that is, an increase in postprandial TG concentrations after high-fat diets or high-fat meals (Georgopoulos et al, 1998;Koutsari et al, 2000;Pieke et al, 2000;Iovine et al, 2004a).…”
Section: Introductionmentioning
confidence: 99%
“…A recent study [14] has observed in humans an increase in HDL cholesterol concentrations by increasing SFA intake (from 8.4 to 11% TE), while plasma apo A-I concentration and LCAT activity both decreased (P < 0.02). On the other hand, in hypertriglyceridemic patients, a high-fat diet significantly increased HDL cholesterol and LCAT, while a subsequent low-fat diet decreased HDL cholesterol and LCAT [15]. Recently, Wood et al [16] showed that a carbohydrate restriction diet (i.e.…”
Section: Introductionmentioning
confidence: 97%
“…In adults, a low-carbohydrate diet with monounsaturated fat enrichment significantly decreased TGs by a mean of 63 %, with associated increases in HDL-C [89]. One year follow-up of 21-month-old children with elevated TGs treated with a carbohydrate-restricted diet showed a decrease in sugar and carbohydrate intake associated with a TG decrease from a mean of 274.1 +/− 13.1 mg/dL before treatment to 88.8 +/− 13.3 mg/dL [90].…”
Section: Management Lifestyle Changementioning
confidence: 97%