Treatment of
            <i>Demodex</i>
            ‐associated inflammatory skin conditions: A systematic review

Jacob, Sherin; VanDaele, Madeline A.; Brown, Jamie N.

doi:10.1111/dth.13103

Cited by 49 publications

(35 citation statements)

References 23 publications

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“…An acaricidal effect of permethrin cream applied twice daily was reported in two controlled studies [220,221], and this treatment was proposed as a valuable option in a recent review [222].…”

Section: Experimental and Clinical Studiesmentioning

confidence: 99%

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Forton¹

2020

Dermatol Ther (Heidelb)

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Rosacea is an inflammatory continuum, with all characteristics being already present from the onset of the disease, even if not clinically visible. Demodex proliferation also appears to be a continuum process in rosacea, and high Demodex density is beginning to be accepted as an important trigger of the inflammatory cascade and as a marker of rosacea: moreover, papulopustules of rosacea can be treated using acaricides. Immunological studies are providing new hypotheses according to which Demodex may induce tolerogenic dendritic cells and collaborate with VEGF to induce T cell exhaustion favoring its own proliferation. This proliferation may not be clinically visible initially. The interactions among VEGF, Demodex, and immunity need to be explored, and the nosology of rosacea definitions adapted accordingly. The effectiveness of treating any patient who only has visible vascular symptoms with an acaricidal cream needs to be confirmed in prospective controlled clinical trials with long-term follow-up, but it is already important to detect patients with pityriasis folliculorum among those with only vascular symptoms of rosacea in order to treat at least these patients with an acaricidal cream. DIGITAL FEATURES This article is published with digital features to facilitate understanding of the article. You can access the digital features on the article's associated Figshare page. To view digital features for this article go to

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Section: Experimental and Clinical Studiesmentioning

confidence: 99%

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Forton¹

2020

Dermatol Ther (Heidelb)

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“…Therefore, such case reports may be a clue for doctors for recognition of the cause of lesions in patients. To date, no standard for demodicosis treatment has been established 23 . The facial skin lesions described in this case only disappeared when ivermectin was included in the treatment.…”

Section: Discussionmentioning

confidence: 84%

Primary facial demodicosis as a health problem and aesthetic challenge: A case report

Przydatek‐Tyrajska

Sędzikowska

Bartosik

2020

J of Cosmetic Dermatology

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Colonization of skin by Demodex mites developing as a single facial lesion with a limited range is diagnosed relatively rarely. The presence of this type of skin lesions may hinder and thus delay the diagnostic process and application of appropriate treatment. The persistent cosmetic defect on the face is extremely onerous/embarrassing to the patient and impedes normal functioning. Describe a case of atypical presentation of primary facial demodicosis and its successful treatment. We present a case of a 38‐year‐old patient who consulted an aesthetic medicine doctor about a skin lesion, that is, erythematous‐papular lesion with single pustules persisting for more than half a year around the right eye corner and below the lower eyelid. Previous topical antibiotic treatment has proved ineffective. Diagnosis was targeted at detection of Demodex spp. invasion, which yielded a positive result. Targeted therapy with 1% topical ivermectin was implemented. Complete resolution of the skin lesions was observed after 8.5 weeks of the treatment with no further recurrence. In the case of limited scaly erythematous‐papular skin lesions with single pustules, Demodex mites should be considered as an etiological factor or one of the factors in the case of a mixed‐etiology lesion. A delayed diagnosis of visible lesions on facial skin has a negative impact on patient's well‐being and normal functioning. As diagnosis of primary demodicosis is underestimated, knowledge about this dermatosis and its clinical manifestations should be disseminated among cosmetologists and doctors of various specialties.

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“…Demodex is a mite that has been linked to chronic inflammation in a variety of areas. Conditions commonly associated with Demodex mites include dermatitis, rosacea, folliculitis, otitis, and blepharitis (5). Thus, cases of rosacea successfully treated with oral ivermectin and topical permethrin have been reported in the literature (6,7).…”

Section: Discussionmentioning

confidence: 99%

Use of permethrin in the treatment of rosacea fulminans during pregnancy: One case report

Garayar-Cantero

Solovera

García

et al. 2020

Dermatologic Therapy

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Rosacea fulminans (RF) is a rare dermatological condition which occurs exclusively in women and it is characterized by a sudden onset of painful papules, pustules, cysts, and nodules on the face. A 28‐year‐old woman was referred to our clinic due to a painful facial eruption within the 13th week of her second pregnancy. After physical examination, the diagnosis of RF during pregnancy was established. Several treatments were used: mupirocin ointment, topical zinc oxide, topical erythromycin, oral erythromycin, metronidazole gel, oral metronidazole, oral amoxiciline, and oral prednisone. Finally, the patient was started on 5% permethrin cream with complete clearing of the lesions. Nowadays, a wide range of treatments for rosacea is available: topical metronidazole, oral metronidazole, topical ivermectin, oral tetracyclines, oral isotretinoin, systemic steroids, photodynamic therapy, or pulsed dye laser. However, in pregnant patients, the treatment alternatives are limited. We consider that 5% permethrin cream could be an effective, cheap, and safe treatment not only in regular patients with rosacea but also in pregnant women, representing an important alternative in the context of pregnancy when therapeutic options are limited. To our knowledge, this is the first case of rosacea treated with 5% permethrin cream in monotherapy during pregnancy.

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Treatment of Demodex ‐associated inflammatory skin conditions: A systematic review

Cited by 49 publications

References 23 publications

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Primary facial demodicosis as a health problem and aesthetic challenge: A case report

Use of permethrin in the treatment of rosacea fulminans during pregnancy: One case report

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