1978

DOI: 10.1258/002367778781088413

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Treatment of Pasteurella pneumotropica abscesses in nude mice (nu/nu)

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Cited by 25 publications

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“…pneumotropica is present in many rodent colonies, especially mice, rats and hamsters. The organism is detected typically in the upper respiratory tract, oral cavity, conjunctiva, bladder, mammary glands, genital tract and feces [1,7,8,16,[18][19][20][21]24]. Latent infections are common in both conventional and barrier-maintained colonies [18,19], and other animals and humans have also been infected by this organism [2,17].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Forced-air-ventilated Micro-isolation System for Protection of Mice against Pasteurella pneumotropica.

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et al. 2003

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Studies to date have established that the physical environment inside cages can be controlled adequately by setting the intra-cage ventilation at 60 air changes per hour in a forced-air-ventilated micro-isolation system (FVMIS). In this study, the capability of FVMIS to prevent inter-cage transmission of microorganisms was evaluated using Pasteurella pneumotropica as a reference microorganism. One FVMIS rack and a conventional rack were used, and cages with mice positive for P. pneumotropica and those with P. pneumotropica-free mice were housed on both racks. The mice were examined for P. pneumotropica contamination every 4 weeks after initiating the experiment for 12 weeks using a polymerase chain reaction method. Some P. pneumotropica-free mice housed in open air cages in the conventional rack became positive for P. pneumotropica (four of 28 animals after 4 weeks; eight of 28 animals after 12 weeks), but all P. pneumotropica-free mice housed in the FVMIS cages remained negative for the bacterium throughout the experiment. The results demonstrate that FVMIS can prevent inter-cage transmission of P. pneumotropica when proper cage handling practice is under taken.

“…pneumotropica is present in many rodent colonies, especially mice, rats and hamsters. The organism is detected typically in the upper respiratory tract, oral cavity, conjunctiva, bladder, mammary glands, genital tract and feces [1,7,8,16,[18][19][20][21]24]. Latent infections are common in both conventional and barrier-maintained colonies [18,19], and other animals and humans have also been infected by this organism [2,17].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Forced-air-ventilated Micro-isolation System for Protection of Mice against Pasteurella pneumotropica.

²

,

³

et al. 2003

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Studies to date have established that the physical environment inside cages can be controlled adequately by setting the intra-cage ventilation at 60 air changes per hour in a forced-air-ventilated micro-isolation system (FVMIS). In this study, the capability of FVMIS to prevent inter-cage transmission of microorganisms was evaluated using Pasteurella pneumotropica as a reference microorganism. One FVMIS rack and a conventional rack were used, and cages with mice positive for P. pneumotropica and those with P. pneumotropica-free mice were housed on both racks. The mice were examined for P. pneumotropica contamination every 4 weeks after initiating the experiment for 12 weeks using a polymerase chain reaction method. Some P. pneumotropica-free mice housed in open air cages in the conventional rack became positive for P. pneumotropica (four of 28 animals after 4 weeks; eight of 28 animals after 12 weeks), but all P. pneumotropica-free mice housed in the FVMIS cages remained negative for the bacterium throughout the experiment. The results demonstrate that FVMIS can prevent inter-cage transmission of P. pneumotropica when proper cage handling practice is under taken.

“…In immunocompetent animals, clinical diseases are not commonly observed. However, immunodeficient animals develop mild to severe or lethal diseases [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Experimental Contact Infection of NOD/ShiJic-scid Mice with Pasteurella pneumotropica

2017

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Background: Pasteurella pneumotropica is a Gram-negative bacterium that infects the laboratory rodents. In immunodeficient animals, P. pneumotropica infection develops mild to severe or lethal diseases. However, little is known about the transmissibility and pathogenesis of P. pneumotropica in immunodeficient mice. In this study, to assess transmissibility and its pathological conditions by P. pneumotropica, experimental contact infection model of NOD/ShiJic-scid mice was examined with clinical and pathological approaches.

“…6 Antimicrobial treatment has frequently been recommended as an alternative method for the elimination of P. pneumotropica from laboratory rodents. 6,10,13,20 Ueno et al 20 reported that the administration of enrofloxacin (a fluoroquinolone) was effective in eliminating this pathogen from infected animals. Enrofloxacin is generally considered to target DNA gyrase and topoisomerase IV that are functional enzymes involved in controlling the topological state of DNA during replication and transcription in prokaryotes.…”

mentioning

confidence: 99%

Comparison of the in Vitro Susceptibility of Rodent Isolates of Pseudomonas Aeruginosa and Pasteurella Pneumotropica to Enrofloxacin

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et al. 2007

J VET Diagn Invest

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Abstract. The objectives of this study were to determine and compare the in vitro enrofloxacin susceptibility of 94 Pseudomonas aeruginosa isolates obtained from enrofloxacin-treated and untreated mice and that of 40 Pasteurella pneumotropica strains and also to assess the efficacy and effects of enrofloxacin treatment of laboratory mice. The minimum inhibitory concentrations (MICs) of enrofloxacin against all the Ps. aeruginosa isolates were in the range of 1 to 4 mg/ml, whereas those against all the P. pneumotropica strains were less than 0.5 mg/ml. The mutation frequency in 54% of the Ps. aeruginosa isolates on treatment with enrofloxacin ranged from 10 26 to 10 28 ; however, none of the P. pneumotropica strains could grow on medium containing more than 3 mg/ml enrofloxacin. Comparison of in vitro enrofloxacin susceptibilities suggested that enrofloxacin was effective for eliminating P. pneumotropica but not for eliminating Ps. aeruginosa for which the MIC of enrofloxacin was more than 1 mg/ml. These results indicated that the enrofloxacin susceptibility of P. pneumotropica was higher than that of Ps. aeruginosa, and that the enrofloxacin treatment might not affect the susceptibility of Ps. aeruginosa.

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