Treatment of idiopathic hypercalciuria and its impact on associated diseases

Liern, Miguel; Bohorquez, Mónica; Vallejo, Graciela

doi:10.5546/aap.2013.eng.110

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…O tratamento hoje preconizado para essa condição inclui ingestão hídrica abundante, reposição de citrato de potássio e diuréticos tiazídicos, além de dieta normocalcêmica e com restrição de sódio e de proteínas animais 18,[20][21][22] .…”

Section: Discussionunclassified

Hiperparatireoidismo associado a hipercalciúria primária em paciente apresentando litíase renal recorrente

Pigossi

Pedroso

Mattos

et al. 2023

Rev. Med. (São Paulo)

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A litíase urinária acomete 5 a 10% da população brasileira e têm uma taxa de recidiva após a primeira crise de até 50% em cinco a dez anos. A hipercalciúria é a mais frequente alteração metabólica encontrada nesses pacientes com cálculos renais e pode ser caracterizada de três formas: (1) absortiva (intestinal), (2) renal e (3) reabsortiva (óssea). OBJETIVO: Descrever o caso de uma paciente com nefrolitíase de repetição associada a hipercalciúria e discutir sobre a associação com hiperparatireoidismo secundário. MATERIAIS E MÉTODOS: As informações foram obtidas por meio de revisão do prontuário, entrevista com o paciente, registro fotográfico dos métodos diagnósticos aos quais a paciente foi submetida e revisão da literatura. CONCLUSÃO: Calculoses causadas por hipercalciúria primária sustentada podem causar hiperparatireoidismo secundário à hipocalcemia, de forma a ser necessário diagnóstico diferencial com hiperparatireoidismo primário e outras causas de hiperparatireoidismo secundário.

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Section: Discussionunclassified

Hiperparatireoidismo associado a hipercalciúria primária em paciente apresentando litíase renal recorrente

Pigossi

Pedroso

Mattos

et al. 2023

Rev. Med. (São Paulo)

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“…In studies, the incidence of IH was determined as 28-35% in patients with microscopic or macroscopic haematuria (8,9). Although microscopic haematuria progresses asymptomatically in IH, there can sometimes be dysuria and suprapubic pain with (22), haematuria (43%) was the most common cause of admission. In our study, patients applied to hospital with abdominal pain and UTI and then haematuria as the third complaint.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Cases Followed with Idiopathic Hypercalciuria in Childhood, Long-term Follow-up Results and Retrospective Evaluation of Complications

Köker¹,

Bayram²,

Soylu³

et al. 2020

meandros

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Bu çalışmada idiyopatik hiperkalsiüri (İH) tanısı ile izlenen çocuk hastaların klinik, laboratuvar, görüntüleme bulgularının, tedavi şekillerinin ve uzun süreli sonuçlarının değerlendirilmesi amaçlanmıştır. Objective: The objective of this study is to assess clinical, laboratory and imaging findings, treatment styles and long-term outcomes of paediatric patients followed with idiopathic hypercalciuria (IH). Materials and Methods: We retrospectively evaluated and reviewed the files of patients aged between 3 months and 18 years with respect to age at the time of diagnosis, gender, admission complaints, follow-up period, laboratory and imaging findings (routine urinary analysis, blood and urinary biochemistry, parathormone, vitamin D level, urinary system ultrasonography and bone mineral density), onset and follow-up anthropometric data and complications. Results: The average ages of male and female patients (total: 52) diagnosed with IH were 30 and 22 years, respectively. The follow-up periods of male and female patients were 44.5±40.8 and 22.5±3.2 (6-96) months. The most frequent admission complaints were abdominal pain and underlying urinary tract infection (UTI) and history of haematuria. The average calcium level at the time of admission was 6.56±2.65 mg/kg/day, and the average calcium/creatinine level was 0.85±0.68 mg/mg. Kidney stones were determined in 41 (79%) patients. In total, 21 (40%) patients had UTI. During follow-up, UTI developed in 6 (11.5%) of them. Following medical treatment and/or nutrition recommendations, there was a reduction in the frequency of UTI rate, haematuria and enuresis (10/11 vs 6/25, p=0.030; 8/8 vs 3/33, p=0.001; and vs 1/46, p<0.001, respectively). Conclusion: Children with IH can apply with different clinical pictures and their conditions can lead to complications such as kidney stones, UTI. However, hypercalciuria, clinical complaints and complications can regress thanks to medical treatment or nutrition recommendations.

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“…Clinical research revealed increased destruction and reduced bone mass in patients with calcium urolithiasis. Some studies indicated that hypercalciuria and increased excretion of potassium, which are present in majority of urolithiasis patients, turned out to be major risk factors for osteoporosis and bone fracture in postmenopausal women (3)(4)(5)(6)(7). In their study, Denburg et al also concluded that urolithiasis is associated with high incidence of bone fracture, especially in women older than 70 (8).…”

Section: Pathophysiological Mechanismsmentioning

confidence: 99%

Association of Urolithiasis With Osteoporosis in Postmenopausal Women: Risk Predictors for the Disease

Bijelic¹,

Miličević²

2020

QOL

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Urolithiasis and osteoporosis are two significant multifactorial diseases that cause the constant increase in the number of affected persons due to the increased age of population and negative effects of environmental factors, i.e. unhealthy lifestyle. Those affected by urolithiasis have an increased risk for osteoporosis. Association of urolithiasis and osteoporosis in postmenopausal women is still not completely understood, but it is certain that those diseases may cause serious consequences leading to the permanent disability and even death due to osteoporotic hip fractures. This is why those disorders remain very significant social, economic and health problems not only for those affected but for the whole society, due to very high treatment costs. Identification of risk factors for menopausal women aims at decreasing the rate of disease and improving of preventive measures. Since both disorders are preventable, preventive measures should be applied from young age, with identification of risk factors being extremely important for significant decrease of morbidity rate.

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Treatment of idiopathic hypercalciuria and its impact on associated diseases

Cited by 7 publications

References 13 publications

Hiperparatireoidismo associado a hipercalciúria primária em paciente apresentando litíase renal recorrente

Hiperparatireoidismo associado a hipercalciúria primária em paciente apresentando litíase renal recorrente

Clinical Features of Cases Followed with Idiopathic Hypercalciuria in Childhood, Long-term Follow-up Results and Retrospective Evaluation of Complications

Association of Urolithiasis With Osteoporosis in Postmenopausal Women: Risk Predictors for the Disease

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