Treatment of imipramine-induced hyperpigmentation with quality-switched ruby and picosecond lasers

Hamid, Ramiz N; Yang, Rachel G.

doi:10.1016/j.jdcr.2021.09.004

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…The patient was unfortunately lost to follow‐up after initiating this treatment. Various forms of laser therapy have shown efficacy in treating refractory pigmentation 2,12,15 . Importantly for our case, both imipramine‐induced hyperpigmentation and exogenous ochronosis have been successfully treated with Q‐switched alexandrite laser therapy 2,12,15 …”

Section: Discussionmentioning

confidence: 83%

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Novel hyperpigmentation pathophysiology following a prolonged course of imipramine therapy

McKenna,

Wold,

Noland

et al. 2023

J Cutan Pathol

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Imipramine is a tricyclic antidepressant typically reserved for patients with treatment‐resistant mood disorders. A rare side effect of long‐term use of imipramine is a slowly progressive melanin‐associated, slate gray‐blue hyperpigmentation of the skin in a photo‐distributed pattern. We report a case of imipramine‐induced hyperpigmentation developing 50 years after initiating imipramine therapy, whose lesions were essentially devoid of melanin on histopathological exam. This differs from all other reported cases of imipramine‐induced hyperpigmentation in two notable respects. First, the time between initiating imipramine therapy and the onset of pigmentation changes was nearly 30 years longer than prior case reports. Second, the lack of melanin in our samples suggests a divergence from the hypothesized melanin‐imipramine complex mechanism of hyperpigmentation. Instead, we propose a novel pathogenesis of imipramine‐induced hyperpigmentation that is unrelated to melanin.

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Section: Discussionmentioning

confidence: 83%

“…Most patients have a resolution of discoloration after discontinuing the offending agent. 2,12,15 However, the risk of recurrence of psychiatric symptoms upon imipramine therapy cessation can outweigh hyperpigmentation. Drug-induced hyperpigmentation is typically resistant to skin-lightening agents such as hydroquinone.…”

Section: Discussionmentioning

confidence: 99%