Treatment of infectious arthritis of the radiocarpal joint of cattle with gentamicin‐impregnated collagen sponges

Abstract

Gentamicin-impregnated collagen sponges were used successfully in the treatment of chronic septic arthritis of the radiocarpal joint in two cattle. Both animals were moderately to severely lame and refractory to systemic antibiotics, and one of them was refractory to joint lavage and local antibiotics. The clinical diagnosis was confirmed by radiography and arthrocentesis. Arthroscopy was performed under general anaesthesia and, after debridement and lavage of the joint, gentamicin-impregnated collagen sponges were placed intra-articularly. Synovial fluid was sampled at 10 and 20 days after surgery and radiographs were taken three months (case 1) and two months (case 2) after surgery. The infection was eliminated from both animals and they recovered without residual lameness.

Palmar arthroscopic approach and intra‐articular anatomy of the bovine carpal joints

“…Arthroscopic examination of the carpal joint in cattle is frequently indicated for diagnostic and prognostic evaluation (septic arthritis and less frequently in cases of osteochondritis dissecans, degenerative joint disease, subchondral bone cysts, and cartilage or ligament injury) and therapeutic intervention (dislodging of free osseous fragments, debris, and fibrin). [8][9][10][11] Arthroscopy has all the advantages of minimally invasive surgery. It improves evaluation of the articular cartilage, allows evaluation of joint capsule pouches and intraarticular structures, decreases hospitalization time, supports extensive joint lavage by flushing large volumes of fluid, and speeds up recovery.…”

Gentamicin concentrations in synovial fluid obtained from the tarsocrural joints of horses after implantation of gentamicin-impregnated collagen sponges

“…16 A similar collagen sponge containing 130 mg of gentamicin has been used to treat horses and cattle with septic arthritis, many of which were refractory to conventional treatment. 14,18,30 Concentrations of gentamicin in synovial fluid after implantation of a gentamicin-impregnated collagen sponge and the effects of the implant on the joint are unknown.…”

“…The delivery of systemically administered antimicrobials to infected synovial tissues can be hindered by chronic inflammation and thrombosis of the synovium, which results in low intra-articular concentrations. 3,9,[15][16][17][18] Intra-articular concentrations that exceed the in vitro MIC of any causative organisms do not ensure clearance of the infection because of the inoculum effect of large numbers of bacteria, protein binding of antimicrobials, seclusion of bacteria within fibrin and synovial crypts, and a decrease in pH within septic joints. 1,3,9,14,15,19 Local antimicrobial delivery is used to Objective-To determine synovial fluid gentamicin concentrations and evaluate adverse effects on the synovial membrane and articular cartilage of tarsocrural joints after implantation of a gentamicinimpregnated collagen sponge.…”

Arthroscopic Diagnosis and Comparison of Arthroscopic Lavage and Intraarticular Antibiotic Applications in the Treatment of Experimentally Induced Different Stage Septic Arthritis in Goats

“…Septi k artriti s (SA), çift lik hayvanlarında ve özellikle at ve sığırlarda en önemli problemdir [1][2][3] . SA, periarti küler dokuda oluşan travmati k lezyonların enfekte olması .…”