1989
DOI: 10.1530/acta.0.120s047
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Treatment of iodine deficiency goiter with iodine vs. levothyroxine. Results of a multicenter trial

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Cited by 14 publications
(24 citation statements)
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“…These findings are in contrast to those of Chow and Phillips [27] from England who observed a fall in 1T4 levels and a compensatory rise in TSH in iodinedepleted subjects after 28 days of supplementation with 500 pg iodine. However, Hintze et al [28] reported an increase in serum T4 and fTj concentrations and a slight decrease of basal and TRH-stimulated TSH after treating iodine-deficient subjects with 400 pg iodine/day for 8 months.…”
Section: Discussionmentioning
confidence: 99%
“…These findings are in contrast to those of Chow and Phillips [27] from England who observed a fall in 1T4 levels and a compensatory rise in TSH in iodinedepleted subjects after 28 days of supplementation with 500 pg iodine. However, Hintze et al [28] reported an increase in serum T4 and fTj concentrations and a slight decrease of basal and TRH-stimulated TSH after treating iodine-deficient subjects with 400 pg iodine/day for 8 months.…”
Section: Discussionmentioning
confidence: 99%
“…Pokazano je da se tokom 3 meseca le enja postiže redukcija veli ine strume za 15-40%. Me utim, po prestanku le enja dolazi do ponovnog rasta (13,14). Primena samo T 4 ili T 4 u kombinaciji sa L-T 4 ne razlikuje se u efektima u odnosu na monoterapiju sa L-T 4 , ali je pokazano da efekti le enja T 4 nakon izostavljanja leka duže traju (15).…”
Section: Difuzna-polinodozna Netoksi Na Strumaunclassified
“…Primena samo T 4 ili T 4 u kombinaciji sa L-T 4 ne razlikuje se u efektima u odnosu na monoterapiju sa L-T 4 , ali je pokazano da efekti le enja T 4 nakon izostavljanja leka duže traju (15). I pored izvesnih neslaganja prihva eno je da uspeh le enja zavisi od stepena supresije TSH, da L-T 4 dovodi do bolje supresije TSH u pore enju sa jodom i da su efekti le enja difuznih struma bolji u pore enju sa nodoznim (10). Nema ki tiroidolozi predlažu da se u le enju difuznih endemskih struma u prvih 6 meseci primeni 200 g joda u kombinaciji sa 100 g L-T 4 a zatim nastavi samo sa jodom (16).…”
Section: Difuzna-polinodozna Netoksi Na Strumaunclassified
“…The efficacy of iodine supplementation, once a nodular goitre has developed, has only very scarcely been evaluated. It seems that iodine is no better than L-thyroxine (L-T4) for goitre reduction in comparative trials [14]. A major hindrance in the use of iodine supplementation, however, is the fact that a sudden increase of the iodine intake may induce thyrotoxicosis in predisposed individuals [15].…”
Section: Iodine Supplementationmentioning
confidence: 99%
“…The efficacy of thyroid hormones depends on the degree of TSH suppression [17,18], although results have been conflicting [20]. In some of the studies, in which L-T4 was compared [14,20] or combined [14] with iodine supplementation, no substantial differences were found between the regimens, but L-T4 resulted in a more pronounced depression of serum TSH than did iodine. Comparing nodular and diffuse goitres, the effect of L-T4 is clearly more convincing in diffuse glands.…”
Section: L-thyroxine Suppressive Therapymentioning
confidence: 99%