Treatment of Kaposi sarcoma in children with HIV-1 infection

Triple therapy of vincristine, bleomycin and etoposide for children with Kaposi sarcoma: Results of a study in Malawian children

“…Studies have shown that a combination of ART and chemotherapy in HIV‐KS leads to better outcomes than either treatment alone . Questions still remain as to what is the best chemotherapy option for disease reduction and for quality of life.…”

“…Studies have shown that a combination of ART and chemotherapy in HIV-KS leads to better outcomes than either treatment alone. 19,20 Questions still remain as to what is the best chemotherapy option for disease reduction and for quality of life. Adult studies report that triple drug regimens are better than single or dual drug regimens [21][22][23] Few studies have adequately studied the impact of chemotherapy on KS in children or the most appropriate chemotherapy regimen, especially in resource-limited settings.…”

Kaposi Sarcoma of Childhood: Inborn or Acquired Immunodeficiency to Oncogenic HHV‐8

“…As in adults, the control of HIV and the switch or diminution of immunosuppression is key to the control of epidemic and iatrogenic forms. In cases of epidemic KS, The Cochrane review concluded that chemotherapy and HAART in combination versus HAART alone are more likely associated with KS remission, although data are sparse . Children with endemic (African) KS who are HIV negative, oftentimes in resource‐limited settings, have better outcomes than those with HIV infection undergoing the same chemotherapeutic regimens .…”

“…In cases of epidemic KS, The Cochrane review concluded that chemotherapy and HAART in combination versus HAART alone are more likely associated with KS remission, although data are sparse. [64,65] Children with endemic (African) KS who are HIV negative, oftentimes in resource-limited settings, have better outcomes than those with HIV infection undergoing the same chemotherapeutic regimens. [20,56,[65][66][67][68] Limited cases of pediatric iatrogenic (liver transplant) KS have shown promising response to mTOR inhibitor sirolimus, and paclitaxel chemotherapy.…”

Rare Skin Tumours in Childhood: Review

“…İyat-rojenik ve epidemik form benzer klinikle seyreder, fakat her yaşta görülebilir. 25 Tedavide kemoterapi ve/veya antiretroviral terapi uygulanmaktadır. 26 …”