Treatment of localized inoperable neoplasms with intra-arterial infusions of 8-azaguanine

Continuous Intra-Arterial Infusion and Intermittent Intra-Arterial Injection

“…We thought that these disappointing results might have been influenced by our selection of cases; most patients had hopelessly advanced disease and had usually been subjected to previous surgery and/or irradiation. Indeed, a review of the literature indicates similar results in roughly comparable series (Sullivan 1962, Hall et al 1962.…”

Cancer Chemotherapy with Purine and Pyrimidine Analogues

“…Although AzG has not been found useful in clinical cancer chemotherapy when given systemically, it has been reported by Hall ct al. (15) to produce temporary objective responses in 30 per cent of patients with head and neck cancer by continuous intra-arterial infusion. 6-Mercaptopurine (6-MP).-This compound (IV, Fig.…”