Treatment of lymphangioma with interferon-alpha-2a

Souza, R J; Tone, Luíz Gonzaga

doi:10.2223/jped.193

Cited by 7 publications

(7 citation statements)

References 18 publications

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“…Therefore, recurrence represents an important problem, with a prevalence rate between 0% and 27% after total exeresis and between 15% and 53% after partial exeresis. [2,13,14].…”

Section: Discussionmentioning

confidence: 99%

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Simultaneous hemopericardium, hemoperitoneum and hemothorax after complete surgical resection of mediastinal cystic lymphangioma: A case report

Kumba¹,

Banchini²,

Conti³

et al. 2017

IJCRI

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“…Therefore, recurrence represents an important problem, with a prevalence rate between 0% and 27% after total exeresis and between 15% and 53% after partial exeresis. [2,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…This could explain blood effusion far from surgical site in the patient. In literature surgical complications, which occur in 19-33% of the cases, include formation of hematoma, lymphocele, scar, abscess, infection, wound dehiscence and nerve palsy have been noticed by several authors [14,[16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Simultaneous hemopericardium, hemoperitoneum and hemothorax after complete surgical resection of mediastinal cystic lymphangioma: A case report

Kumba¹,

Banchini²,

Conti³

et al. 2017

IJCRI

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“…There are several treatment options for LMs, including surgery and sclerotherapy , laser therapy , and pharmacotherapy such as sirolimus , sildenafil , and interferon‐alpha treatment . None of these treatments is uniformly effective, and all have potential side effects.…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy of Herbal Medicine for Pediatric Lymphatic Malformations: A Pilot Study

Hashizume

Yagi

Egami

et al. 2016

Pediatric Dermatology

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BackgroundLymphatic malformations (LMs) are congenital malformations of the lymphatic system that commonly affect the head and neck region and cause marked cosmetic and functional complications. In this pilot study, we present eight children with LMs treated using an herbal medicine for this indication.MethodsBetween January 2009 and May 2014, eight children (four boys, four girls) with LMs were treated using oral administration of an herbal medicine, Eppikajyutsuto (TJ‐28; Tsumura, Tokyo, Japan), as monotherapy.ResultsFour of the cases were macrocystic and four were mixed micro‐ and macrocystic. The mean treatment duration was 7.2 ± 2.9 months (range 5–12 mos). The mean LM volume shrinkage on magnetic resonance imaging was 54.5 ± 38.3% (macrocystic 73.6 ± 27.0%; mixed micro‐ and macrocystic 35.4 ± 41.5%). One of four macrocystic lesions had a marked reduction, two had a moderate reduction, and one had no response. A marked reduction was observed in three of the four mixed micro‐ and macrocystic cases; the other mixed cystic case had no response. The treatment was well tolerated, without severe adverse events.ConclusionsThis preliminary study demonstrates the beneficial effects of TJ‐28. Further evaluations of this therapeutic modality are warranted.

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“…The limitations of surgical treatment have awoken the interests in other therapeutic methods. The administration of sclerosing agents such as bleomycin and hypotonic salt solutions provokes an inflammation of the vascular endothelium leading to total or partial remission of human lymphangioma (7)(8)(9)(10)(11). These substances may extend beyond the limits of the original lymphangioma, unsatisfactory aesthetic results and increased difficulties for future surgery.…”

Section: Introductionmentioning

confidence: 99%

Isolation and characterization of lymphatic endothelial cells from human glossal lymphangioma

You

Wu²,

Chen³

et al. 2009

Oncol Rep

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Abstract. Abnormal lymphangiogenesis is associated with several diseases such as tumor metastasis and lymphangioma. Human lymphangioma originated from the transformation of lymphatic endothelium is a benign malformation of lymphatic vessels and its pathogenesis has up to date not been illuminated and its cell model has also not been established. An optimized method was used to isolate lymphatic endothelial cells from human glossal lymphangioma (GL-LECs) and GL-LECs were further primarily cultured and expanded. GL-LECs were of typical cobblestone appearance when they reached confluence. The Weible-palade body was observed in the GL-LECs cytoplasm. Almost all GL-LECs were strongly positive for specific lymphatic markers FLT-4, LYVE-1 and prox-1 by immunocytochemistry. Furthermore, threedimension tube-like capillaries of GL-LECs resembled the lymphatic system in vivo, and the GL-LECs spheroids sprouted radically out to form three-dimensional buds when embedded in the cultured BME. These results indicated that high purity GL-LECs were successfully isolated and expanded. They had the abilities of tube formation and differentiation in vitro, which provide a favorable cell model for further uncovering the pathogenesis of human lymphangiomas. IntroductionThe lymphatic system is made up of an extensive network of lymphatic capillaries, with functions of collecting interstitial fluid, macromolecules and even pointing leukocytes or tumor cells into the circulation system. Therefore, it plays a pivotal role in mediating tissue fluid homeostasis, tumor metastasis and immunological functions. Although the lymphatic system was discovered about 300 years ago, these functions have just been investigated in recent years due to the lack of the specific lymphatic markers. Recently, fms-like tyrosine kinase 4 (FLT-4), lymphatic endothelial hyaluronan receptor (LYVE-1), Prox-1, and podoplanin have been identified as the specific lymphatic endothelial cell markers and largely restricted to lymphatics in adult tissues (1-6), which provided new insights into the molecular mechanisms of lymphatics in physiologic functions and pathologic processes such as inflammations, tumor metastasis, lymphedema and lymphangioma. Human lymphangioma, which is a kind of benign tumor originated from lymphatic vessels, is largely diagnosed in children and has always been defined as congenital malformations. Although human lymphangiomas are asymptomatic in the early course, they develop and have characteristics of progressive growth, compression and infiltration into adjacent tissues. The most acceptable therapy for human lymphangioma is surgery at present, but it has many limitations such as the risk of complications and recurrence. The limitations of surgical treatment have awoken the interests in other therapeutic methods. The administration of sclerosing agents such as bleomycin and hypotonic salt solutions provokes an inflammation of the vascular endothelium leading to total or partial remission of human lymphangioma (7-11). These substances may extend...

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Treatment of lymphangioma with interferon-alpha-2a

Cited by 7 publications

References 18 publications

Simultaneous hemopericardium, hemoperitoneum and hemothorax after complete surgical resection of mediastinal cystic lymphangioma: A case report

Simultaneous hemopericardium, hemoperitoneum and hemothorax after complete surgical resection of mediastinal cystic lymphangioma: A case report

Clinical Efficacy of Herbal Medicine for Pediatric Lymphatic Malformations: A Pilot Study

Isolation and characterization of lymphatic endothelial cells from human glossal lymphangioma

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