Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods

Wang, Dangge; Xu, Zhiai; Yu, Haijun; Chen, Xianzhi; Feng, Bing; Cui, Zhiwen; Lin, Bin; Zhang, Zhiwen; Chen, Chunying; Wang, Jun; Zhang, Wen

doi:10.1016/j.biomaterials.2014.05.094

Cited by 147 publications

(134 citation statements)

References 43 publications

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“…The 4T1 tumor was selected in this study because it is a well-established lung metastasis breast cancer model. [ 22 ] Two weeks post implant of the primary 4T1 tumor, the metastasis lesion was formed in the lung as confi rmed by histological examination. tumor bearing mice, PNs were used as the controls.…”

Section: In Vivo Pharmacokinetics and Distribution Of Rvpnsmentioning

confidence: 99%

Long Circulation Red‐Blood‐Cell‐Mimetic Nanoparticles with Peptide‐Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer

Sun

Meng

et al. 2016

Adv Funct Materials

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197

126

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Section: In Vivo Pharmacokinetics and Distribution Of Rvpnsmentioning

confidence: 99%

Long Circulation Red‐Blood‐Cell‐Mimetic Nanoparticles with Peptide‐Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer

Sun

Meng

et al. 2016

Adv Funct Materials

Self Cite

197

126

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“…34 The above process is known as apoptosis, and chromatin clumps are used commonly as a marker of drug-induced tumor cell apoptosis. 35 Hence, the DOX-carrying nanoclusters were observed by TEM to determine their apoptotic effects on MCF-7 breast cancer cells (Figure 3). The distorted chromatin clumps (white arrow in Figure 3A and B) and the produced lipid droplets (black arrow in Figure 3A and B) both confirmed the occurrence of FA-DOX@IONP-mediated apoptosis.…”

Section: Fa-dox@ionp-mediated Breast Cancer Cells Apoptosismentioning

confidence: 99%

Theranostic pH-sensitive nanoparticles for highly efficient targeted delivery of doxorubicin for breast tumor treatment

Pan¹,

Liu²,

Zhou³

et al. 2018

IJN

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A multifunctional theranostic nanoplatform integrated with environmental responses has been developed rapidly over the past few years as a novel treatment strategy for several solid tumors. We synthesized pH-sensitive poly(β-thiopropionate) nanoparticles with a supermagnetic core and folic acid (FA) conjugation (FA-doxorubicin-iron oxide nanoparticles [FA-DOX@ IONPs]) to deliver an antineoplastic drug, DOX, for the treatment of folate receptor (FR)-overexpressed breast cancer. In addition to an imaging function, the nanoparticles can release their payloads in response to an environment of pH 5, such as the acidic environment found in tumors. After chemical ( 1 H nuclear magnetic resonance) and physical (morphology and super-magnetic) characterization, FA-DOX@IONPs were shown to demonstrate pH-dependent drug release profiles. Western blotting analysis revealed the expression of FRs in three breast cancer cell lines, MCF-7, BT549, and MD-MBA-231. The cell counting kit-8 assay and transmission electron microscopy showed that FA-DOX@IONPs had the strongest cytotoxicity against breast cancer cells, compared with free DOX and non-FR targeted nanoparticles (DOX@IONPs), and caused cellular apoptosis. The FA-DOX@IONP-mediated cellular uptake and intracellular internalization were clarified by fluorescence microscopy. FA-DOX@IONPs plus magnetic field treatment suppressed in vivo tumor growth in mice to a greater extent than either treatment alone; furthermore, the nanoparticles exerted no toxicity against healthy organs. Magnetic resonance imaging was successfully applied to monitor the nanoparticle accumulation. Our results suggest that theranostic pH-sensitive nanoparticles with dual targeting could enhance the available therapies for cancer.

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“…In addition to photothermal ablation therapy, gold nanoparticles can be loaded with chemotherapeutics to enhance antitumor efficacy. To treat metastatic breast cancer, a Dox loaded DNA wrapped gold nanorod was developed which allowed for dual therapeutic functions, photothermal ablation and chemotherapy 118 . Mice bearing 4T1 mammary tumors were treated with the Dox loaded DNA wrapped gold nanorod and received 655 nm laser irradiation.…”

Section: Current Advances In Cancer Nanotechnology For Tnbcmentioning

confidence: 99%

Targeted nanoparticles for image‐guided treatment of triple‐negative breast cancer: clinical significance and technological advances

Miller‐Kleinhenz

Bozeman

Yang

2015

WIREs Nanomed Nanobiotechnol

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Effective treatment of triple negative breast cancer (TNBC) with its aggressive tumor biology, highly heterogeneous tumor cells, and poor prognosis requires an integrated therapeutic approach that addresses critical issues in cancer therapy. Multifunctional nanoparticles with the abilities of targeted drug delivery and non-invasive imaging for monitoring drug delivery and responses to therapy, such as theranostic nanoparticles, hold great promise towards the development of novel therapeutic approaches for the treatment of TNBC using a single therapeutic platform. The biological and pathological characteristics of TNBC provide insight into several potential molecular targets for current and future nanoparticle based therapeutics. Extensive tumor stroma, highly proliferative cells, and a high rate of drug-resistance are all barriers that must be appropriately addressed in order for these nanotherapeutic platforms to be effective. Utilization of the enhanced permeability and retention (EPR) effect coupled with active targeting of cell surface receptors expressed by TNBC cells, and tumor associated endothelial cells, stromal fibroblasts and macrophages is likely to overcome such barriers to facilitate more effective drug delivery. An in depth summary of current studies investigating targeted nanoparticles in preclinical TNBC mouse and human xenograft models is presented. This review aims to outline the current status of nanotherapeutic options for TNBC patients, identification of promising molecular targets, challenges associated with the development of targeted nanotherapeutics, the research done by our group as well as others and future perspectives on the nanomedicine field and ways to translate current preclinical studies into the clinic.

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Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods

Cited by 147 publications

References 43 publications

Long Circulation Red‐Blood‐Cell‐Mimetic Nanoparticles with Peptide‐Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer

Long Circulation Red‐Blood‐Cell‐Mimetic Nanoparticles with Peptide‐Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer

Theranostic pH-sensitive nanoparticles for highly efficient targeted delivery of doxorubicin for breast tumor treatment

Targeted nanoparticles for image‐guided treatment of triple‐negative breast cancer: clinical significance and technological advances

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