Treatment of Mild to Moderate Plaque Psoriasis with Calcitriol Ointment Applied with or without a Dosing Device

Abstract

Results of topical treatments can be influenced by several factors, including accurate dosing based on the affected skin area. The aim of this open-labelled multicenter study is to evaluate if correct dosing of calcitriol ointment has an impact on the clinical response of plaque psoriasis. For this purpose, patients with plaque psoriasis eligible to be treated with calcitriol ointment were randomized to treatment with a ‘standardized dose’ method, using a dosing device (N. 100), or treatment without the device (N. 101), for 12 weeks. Regardless of the use of the dosing device, calcitriol ointment caused a significant reduction of both the severity of signs and symptoms and the extent of body surface area affected after both 4 weeks and 12 weeks. Clinical response was not significantly different between the two groups. Local adverse events occurred in 12 subjects (of whom five treated with the device) and were mild and transient in most cases.

Microbiological Aspects and Inflammatory Response of Pulp Tissue in Traumatic Dental Lesions

“…al. obtained the same results in teeth with complex radicular coronal fractures where the radicular pulp tissue resulted normal, having dilated and functioning blood vessels (19)(20)(21)(22).…”

Impact of Porcine Orexin a on Glucagon Plasma Concentrations in Pigs

“…The regulation offeeding and energy homeostasis is determined by the hypothalamus, which is the main area of action and, depending on the case, the main area of production of a large number of neuropeptides. Neuropeptides control the huge number of incoming and outgoing signals, which take place in the hypothalamus, since they are basically the carriers of these signal data (30)(31)(32)(33).…”

“…Neuropeptides control the huge number of incoming and outgoing signals, which take place in the hypothalamus, since they are basically the carriers of these signal data (30)(31)(32)(33). The sense of appetite is probably due partly to Orexin A, and partly to the existence of a whole group of neuropeptides acting together in the hypothalamus and the gastrointestinal tract (1-2, 34).…”

Hypertonic Saline Solution in Children with Adenoidal Hyperytrophy: Preliminary Evidence

“…Adenoidal hypertrophy which obstructs the nasal airway in children is associated with numerous symptoms, including: snoring, nasal obstruction, oral breathing, rhinolalia, restsleep, hypersomnolence, and enuresis (2)(3)(23)(24)(25)(26)(27)(28).…”