Treatment of nevus of Ota by Q-switched ruby laser

Taylor, Charles R.; Flotte, Thomas J.; Gange, Richard W.; Anderson, R. Rox

doi:10.1016/s0190-9622(08)81505-8

Cited by 76 publications

(63 citation statements)

References 28 publications

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“…The present study has shown large tense vacuolation (Fig. 4a) immediately after irradiation, although irregularly shaped vacuoles have been reported as an epidermal change in guinea pig skin after ruby laser irradiation [14] and a change of melanocytes in the naevus of Ota [17,19] by Q-switched ruby laser. This discrepancy between tense, round withered, irregularly shaped vacuolations was thought to result from the interval between irradiation and biopsy.…”

Section: Discussioncontrasting

confidence: 52%

Light and electron microscopic investigation of the process of healing of the naevus of Ota by Q-switched alexandrite laser irradiation

et al. 1997

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Melanocytes in the naevus of Ota were destroyed by irradiation using the Q-switched alexandrite laser. This laser is highly selective and highly absorbed by melanosomes. Other cells and tissue components of the dermis remained almost intact. Melanosomes were vaporized or fragmented to subelectron microscopical size, or degenerated. If the irradiated energy was sufficient, melanocytes vanished and large vacuoles several times the size of dermal melanocytes formed at the sites. If it was too weak, dermal melanocytes were also vaporized, but vacuoles formed within them. Nuclei were no longer discernible. Following irradiation macrophages infiltrated the irradiated areas and scavenged degenerated melanosomes and cellular debris. Thus, discoloration of the skin was markedly reduced. Although a few melanocytes and melanophages remained, pigmentation cleared to a satisfactory level. Melanocytes and keratinocytes were also injured in the epidermis; however, the epidermis recovered completely. No scarring was observed.

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Section: Discussioncontrasting

confidence: 52%

Light and electron microscopic investigation of the process of healing of the naevus of Ota by Q-switched alexandrite laser irradiation

et al. 1997

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“…20,21 Melanin is a major skin chromophore of the 755 nm beam of the QS alexandrite laser. 23 We have also found promising results when applying this technique to tattoo removal by ablating the epidermis with the pulsed CO 2 laser immediately before treatment with pigment-specific lasers (unpublished observation). Thus a higher essential fluence of the laser beam is provided to the target-dermal melanin.…”

Section: Discussionmentioning

confidence: 84%

Treatment of Facial Skin Using Combinations of CO2, Q-Switched Alexandrite, Flashlamp-Pumped Pulsed Dye, and Er:YAG Lasers in the Same Treatment Session

Manuskiatti

Fitzpatrick

Goldman

2000

Dermatologic Surgery

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“…The QSRL was the first laser reported to be highly efficacious for the treatment of benign epidermal pigmented lesions [6,7]. The 694 nm wavelength allows for deeper penetration and, thus, improves dermal pigmentation, such as those seen with Nevus of Ota [8]. The collective experience over two decades and the welldocumented efficacy of the QSRL against epidermal and dermal pigmentation make this laser an ideal first-line choice as an adjunct to IPL for CD.…”

Section: Discussionmentioning

confidence: 99%

Combined use of intense pulsed light and Q‐switched ruby laser for complex dyspigmentation among asian patients

Park¹,

Tsao²

2008

Lasers Surg Med

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Background: Dyspigmentation is a common cosmetic concern among Asians. Many individuals exhibit mixed pigmentary entities including melasma, flat/small seborrheic keratoses, ephelides, solar lentigines and acquired bilateral nevus-of-Ota-like macules (ABNOM). We term this phenomenon complex dyspigmentation (CD) and suggest that a combination strategy may be more efficacious than any singular modality. Objective: To determine the effectiveness of combined intense-pulsed light (IPL) for global photorejuvenation along with Q-switched ruby laser (QSRL) for targeted pigment dissolution. Study Design/Materials and Methods: Twenty-five Korean women with CD (defined as > 2 types of facial pigmentary disorders) were initially treated with IPL followed by repeat treatments every 3-4 weeks as needed. The QSRL treatments, set at low fluence, were added either during the same session or within 1 week of the IPL treatment. Improvement was assessed by the patient, the treating physician and a blinded evaluation of pre-and post-treatment photographs. Results: Using a 4-point scale (1 ¼ poor, 2 ¼ fair, 3 ¼ good, 4 ¼ excellent), 19/25 patients (76%) reporting good-to-excellent response (score ''3'' or ''4''). Two independent physician assessment revealed that 15/25 patients (60%) showed 76-100% improvement while 19/25 patients (76%) showed at least 50% improvement. Side-effects were minimal: 3 patients had transient post-inflammatory hyperpigmentation (12%) and 1 patient (4%) had linear hypopigmentation. Conclusions: Combination treatment with IPL and QSRL is an effective and safe treatment for CD among Asian patients.

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Treatment of nevus of Ota by Q-switched ruby laser

Cited by 76 publications

References 28 publications

Light and electron microscopic investigation of the process of healing of the naevus of Ota by Q-switched alexandrite laser irradiation

Light and electron microscopic investigation of the process of healing of the naevus of Ota by Q-switched alexandrite laser irradiation

Treatment of Facial Skin Using Combinations of CO2, Q-Switched Alexandrite, Flashlamp-Pumped Pulsed Dye, and Er:YAG Lasers in the Same Treatment Session

Combined use of intense pulsed light and Q‐switched ruby laser for complex dyspigmentation among asian patients

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