Early Childhood Caries (ECC) is a prevalent and preventable oral health concern among children, presenting unique challenges when managing those with autism and developmental disorders. This paper explores navigating ECC management in this population from a U.S. perspective. Understanding the impact of autism spectrum disorder (ASD) and developmental disorders on oral health is crucial, given their higher risk of ECC due to behavioral, dietary, and hygiene factors. Diagnosis and assessment pose particular challenges, requiring tailored approaches to accommodate sensory sensitivities and communication barriers. Preventive strategies encompass parent/caregiver education, customized oral hygiene instruction, dietary counseling, and fluoride varnish application. Behavioral management techniques, such as desensitization and creating a positive dental experience, are essential for successful treatment. Treatment approaches may involve restorative procedures, considering sedation or anesthesia for children with heightened anxiety or sensory issues, often requiring collaboration with multidisciplinary teams. Long-term management emphasizes maintaining oral health habits and regular dental visits, adjusting to changes in behavior and developmental needs over time. Addressing barriers to care, including access, financial constraints, and provider education, is crucial for effective ECC management in this population. ECC management in children with autism and developmental disorders requires a comprehensive, multidisciplinary approach tailored to individual needs. Future research should focus on refining diagnostic techniques, enhancing preventive interventions, and improving access to dental care services for this vulnerable population. By addressing these challenges, we can strive to improve oral health outcomes and quality of life for children with autism and developmental disorders.