Treatment of Oat-Cell Carcinoma of Bronchus by Preoperative Radiotherapy and Surgery

Bates, Michael; Hurt, Raymond; Levison, V. B.; Sutton, Maurice

doi:10.1016/s0140-6736(74)90619-9

Cited by 44 publications

(4 citation statements)

References 6 publications

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“…about 6% present initially with some large cells, while at autopsy up to 35% of small cell tumors show other histological types of lung cancer or have completely con verted to a nonsmall cell type of morphology [196]. Radiotherapy and chemotherapy can effect changes in tumor morphology and there are numerous examples of small cell carcinomas converting to another morpho logical type, including epidermoid and ade nocarcinomas and large cell carcinomas [197][198][199][200][201]. Long-term cell culture also in duces marked changes in phenotype, includ ing loss of dense-cored granules [202] and a gain in epidermoid specialization [155].…”

Section: Commentmentioning

confidence: 99%

Histogenesis of Preneoplastic and Neoplastic Lesions in Tracheobronchial Epithelium

McDowell¹,

Trump²

1983

Pathol Immunopathol Res

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Section: Commentmentioning

confidence: 99%

Histogenesis of Preneoplastic and Neoplastic Lesions in Tracheobronchial Epithelium

McDowell¹,

Trump²

1983

Pathol Immunopathol Res

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“…The seventh biennial program on current methods of immunologic research and diagnosis will be offered by The Ernest Witebsky Center for Immunology of the State University of New York at Buffalo June [1][2][3][4][5][6][7][8][9][10][11][12][13]1981. This will consist primarily of a combination of core and elective practical laboratory exercises to allow the participant to become acquainted with the techniques by personally carrying them out at the bench complemented by demonstrations, lectures, and discussions.…”

Section: Seventh Summer Program In Methods Of Immunologic Research Anmentioning

confidence: 99%

Small-cell carcinoma of the lung: A five-year experience with combined modality therapy

Hoffman

Golomb

Bitran

et al. 1980

Cancer

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In the past five years, we have treated 89 patients with small-cell carcinoma of the lung with radio-therapy plus one of three chemotherapy programs. The 24 patients with disease confined to the chest (Stage IIIMo) had an 87% response rate to the combined modalities (79% complete responses) and a median survival of 18 months; 13 patients with disease confined to the chest and ipsilateral supraclavic-ular nodes (Stage IIIMoSCN+) had an 84% response rate (69% complete reponses) and 11-month median survival; the 52 patients with distant metastases (Stage IIIMI) had a 71% response rate (15% complete responses) and eight-month median survival. Survival was not affected by adding pro-phylactic cranial irradiation to the latest regimen, although the CNS relapse rate was reduced. We conclude that our three chemotherapy programs to date differ very little in their effect on survival of patients with metastatic disease. New and more vigorous approaches, possibly including surgery, need to be tested for the management of disease confined to the chest. The designation of patients as Stage III,,SCN+ is valid because such patients have better survival rates than patients with distant metastatic disease. Cancer 46:2550-2556. 1980. MALL-CELL CARCINOMA of lung is a disease S with very poor survival rates and for which the local modalities of surgery and radiotherapy have little impact on mortality.25 In the past decade, major advances have been made in the management of this tumor, principally due to the addition of combination chemotherapy programs to local modalities of treatment. These advances have been summarized in several recent reviews.7~16~23~27 Beginning in 1974, patients at the University of Chicago and Michael Reese Medical Center with small-cell bronchogenic carcinoma have been treated aggressively with a series of three successive programs combining radiation therapy and chemotherapy. Our results with 51 patients with two of the programs have been reported previously.5,10 In this paper we report the results of treatment of 38 additional patients with a third program, compare the three programs, and sum

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“…Bates and colleagues reported on 29 patients with tumors initially diagnosed as small cell undifferentiated carcinoma (6 of whom were finally diagnosed as poorly differentiated epidermoid carcinoma) who were treated with preoperative irradiation (1750 rads delivered in 3 days) followed by surgical resection of the tumor. 4 Seven of the twenty-nine patients (24 percent) survived for four years.…”

Section: Small Cell Undifferentiated Carcinomamentioning

confidence: 98%

Radiation Therapy in the Management of Carcinoma of the Lung

Pérez¹

1982

Semin Respir Crit Care Med

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Treatment of Oat-Cell Carcinoma of Bronchus by Preoperative Radiotherapy and Surgery

Cited by 44 publications

References 6 publications

Histogenesis of Preneoplastic and Neoplastic Lesions in Tracheobronchial Epithelium

Histogenesis of Preneoplastic and Neoplastic Lesions in Tracheobronchial Epithelium

Small-cell carcinoma of the lung: A five-year experience with combined modality therapy

Radiation Therapy in the Management of Carcinoma of the Lung

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