Treatment of oral manifestations of toxic epidermal necrolysis with low‐level laser therapy in a pediatric patient

Rocha, Amanda Leal; Souza, Alessandra Figueiredo de; Nunes, Laiz Fernandes Mendes; Cunha, Nayara Dias De Souza; Lanza, Célia Regina Moreira; Travassos, Denise Vieira; Silva, Tarcı́lia Aparecida

doi:10.1111/pde.13719

Cited by 10 publications

(9 citation statements)

References 17 publications

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“…Resulting in analgesic, anti-inflammatory effects and accelerating the wound healing process (Sonis et al, 2016). Some studies have already described positive results from the use of photobiomodulation in oral lesions of TEN and Steven Johnson Syndrome and demonstrated that there were analgesic effects and tissue regeneration (Simões et al, 2011;Rocha et al, 2019). It is also used in other ulcerative disorders such as mucositis and pemphigus vulgaris (Sonis et al, 2016;Dal Prá et al, 2020), photobiomodulation reduces the painful sensation, ensures comfort to the patient and reduces the prescription of analgesics (Soares et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…The photobiomodulation protocol was performed with a portable 100mW (InGaAIP -duo laser / MMOpstics, São Carlos, SP, Brazil) semiconductor device with red light (660 nm) and infrared (808 nm), using 2J for 4 seconds per point, with a distance of 1 cm between points, being applied over the entire length of oral lesions (Rocha et al, 2019). The total application per session was 5-8 minutes.…”

Section: Case Reportmentioning

confidence: 99%

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Oral manifestations and management of toxic epidermal necrolysis in an intensive care unit: case report

Prá

Tristão

Matias

et al. 2022

RSD

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Toxic epidermal necrolysis (TEN) is a mucocutaneous disorder characterized by the detachment of epidermal and mucous tissues and areas of necrosis, resulting from hypersensitivity reactions to different drugs. We report a clinical case of a 19-year-old male patient diagnosed with TEN, with 90% involvement of the body surface and severe oral involvement. The patient was monitored by dentists from the multidisciplinary team of an intensive care unit, where adjuvant treatment was performed through photobiomodulation to control pain and regenerate the oral mucosa. The case represents the importance of early performance in oral TEN injuries and the role of the multidisciplinary team for comprehensive treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Oral manifestations and management of toxic epidermal necrolysis in an intensive care unit: case report

Prá

Tristão

Matias

et al. 2022

RSD

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“…The LLLT is a phototherapy that stimulate tissue regeneration, reduce inflammation, and control pain (Anschau et al, 2019). Previous reports described LLLT in the treatment of oral ulcers of a Stevens-Johnson syndrome patient exhibiting pain relief and improvement in oral functions (Simões et al, 2011;Rocha et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Treatment Following Erythema Multiforme in the Oral Mucosa After qHPV Vaccine with Low-Level Laser Therapy: Case Report

Magalhães¹,

Balbino²,

Araújo

et al. 2021

Int. J. Odontostomat.

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Erythema multiforme (EM) is a mucocutaneous condition of uncertain etiology, although the hypersensitivity reaction to a wide variety of agents may be related to the onset of the lesions. In about half of the affected patients it is possible to identify a previous infection. This article aims to report a case of EM in the oralmucosa after qHPV vaccine (Gardasil®), to highlight the diagnostic process and the proposed treatment. Female patient, 16 years old, after 10 days of receiving the first dose of the qHPV vaccine. On physical examination, she presented multiple ulcers and hemorrhagic crusts to the touch, based on the clinical picture and the history of the disease, a diagnostic hypothesis was EM. Low-level laser therapy (LLLT) was chosen as an alternative treatment, since the exercises applied were not successful. The patient was followed up, reported decreased pain and burn and, after one year of treatment, there was no recurrence of the lesions. Laser treatment showed an effective treatment alternative, in addition to the low cost and ease of application.

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“…Além disso, efeitos na transmissão do impulso nervoso, incluindo alterações no limiar de dor dos nociceptores, libertação de endorfinas e redução da dor aguda foram descritos. 14 Corroborando com os achados da literatura, a aplicação de fotobiomodulação complementar ao uso de elixires orais tópicos reduziu gradativamente as queixas de dor pelo paciente, permitindo a cura das lesões orais e retorno de função como fala e alimentação, não provocando formação de cicatrizes ou fibroses ao final do tratamento.…”

Section: Discussão E Conclusõesunclassified

A importância dos cuidados multiprofissionais no tratamento da síndrome de Stevens-Johnson associada ao uso de Dimaleato de Afatinibe: relato de caso por Equipa de Medicina Dentária Hospitalar

Morais¹,

Sol²,

Rodrigues³

et al. 2021

j.rpemd

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A síndrome de Stevens-Johnson é relatada como uma reação incomum de hipersensibilidade tardia associada principalmente ao uso de medicamentos, e que se manifesta prioritariamente através de erupções cutâneas e ulcerações nas membranas mucosas que revestem a boca, o órgão genital e os olhos. O dimaleato de afatinibe é uma medicação inibidora da tirosina quinase que tem como alvo o recetor do fator de crescimento epidérmico, sendo indicada como monoterapia para o tratamento de carcinoma pulmonar de células não pequenas. A síndrome de Stevens-Johnson é um efeito adverso raro dessa medicação. O presente relato tem por objetivo apresentar um caso clínico de manifestação da Síndrome de Stevens-Johnson em um paciente jovem do sexo masculino após uso de dimaleato de afatinibe para tratamento de um adenocarcinoma pulmonar, com ênfase na perspetiva terapêutica odontológica em relação às manifestações orais de tal condição.

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Treatment of oral manifestations of toxic epidermal necrolysis with low‐level laser therapy in a pediatric patient

Cited by 10 publications

References 17 publications

Oral manifestations and management of toxic epidermal necrolysis in an intensive care unit: case report

Oral manifestations and management of toxic epidermal necrolysis in an intensive care unit: case report

Treatment Following Erythema Multiforme in the Oral Mucosa After qHPV Vaccine with Low-Level Laser Therapy: Case Report

A importância dos cuidados multiprofissionais no tratamento da síndrome de Stevens-Johnson associada ao uso de Dimaleato de Afatinibe: relato de caso por Equipa de Medicina Dentária Hospitalar

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