Treatment of organophosphate poisoning. Experience of nerve agents and acute pesticide poisoning on the effects of oximes

Balali-Mood, Mahdi; Shariat, M

doi:10.1016/s0928-4257(99)80008-4

Cited by 133 publications

(94 citation statements)

References 4 publications

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“…Balali-Mood revealed that hypokalemia may aggravate muscular weakness due to inhibition of AChE by OPC. 22 In our study hypokalemia was most common electrolyte imbalance (24%) like past studies was seen to be associated with significant morbidity and mortality secondary to cardiac arrhythmias and RF. 26 We also found hypokalemia is related to OPC induced muscle weakness as well suggesting alteration in serum K + hamper neuromuscular junction activity and contribute to overall morbidity and mortality in OPC-Poisoning.…”

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confidence: 60%

Study of clinical profile of organophosphorus poisoning with special reference to electrocardiographic changes and electrolyte derangement

et al. 2018

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Background: Organophosphorus Compounds (OPC) are main cause of accidental and suicidal poisoning in agrarian countries like India. Aim was to study the clinical profile of OPC-Poisoning and correlate it with the electrocardiographic (ECG) changes and electrolyte abnormalities.Methods: Hundred consecutive cases admitted to Medicine Department underwent clinical examination, ECG, electrolytes, Acetyl Choline Esterase (AChE) estimation from time to time and Paradeniya Organophosphorus Poisoning (POP) score at the time of admission. All these parameter with duration of hospital stay and outcome were statistically analysed using X2 test, Fisher exact test, and inference was drawn.Results: In hundred OPC-Poisoning patients [Male (n=48), Female (n=52), M: F ratio 0.92:1] with mean age of 37.78±12.95 years, commonest poison was cholropyrifos+cypermethrin and was mostly suicidal (96%). Common symptoms were sweating (48%), salivation, blurring of vision, breathlessness and signs were smell of poison (90%), tachypnea, altered sensorium, miosis and fasciculation. POP scoring found 41% of patients in mild, 26% in moderate and 33% in sever grade of poisoning. Hospital stay ranged from 4-18 days. Complications were pulmonary Edema (PE) in 28%, Respiratory Failure (RF) 18%, Aspiration Pneumonia (AP) 15% and Intermediate Syndrome (IS) 4%. 10 died out of 42 patients who had complications and the cause of death was RF in 4, Ventricular Fibrillation (VF) 2 and IS in 2. ECG finding showed sinus tachycardia (31%), prolonged corrected QT (QTc) interval (28%), sinus bradycardia (25%), ST-T changes (17%) and Premature Ventricular Contraction (PVC) in 4% which degenerated to VF in 2%. 24 patients were Hypokalemic from which 16 developed complications.Conclusions: Similar to earlier studies we observed poisoning which was suicidal. QTc prolongation and Hypokalemia are associated with high morbidity and mortality in OPC-Poisoning.

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confidence: 60%

Study of clinical profile of organophosphorus poisoning with special reference to electrocardiographic changes and electrolyte derangement

et al. 2018

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“…Three of the patients who received the LüH-6 combination therapy developed hepatitis and two of them died due to liver failure, which may indicate overdosage of LüH-6. 107 The usual therapeutic regimen of LüH-6 is comprised of a 250 mg intravenous (or intramuscular) bolus immediately after the first atropine injection. Then if no recovery is apparent during the next 15 to 30 minutes, an intravenous infusion of 750 mg/24 h is started for as long as necessary.…”

Section: Mechanism Of Action Of Pyridinium Oximesmentioning

confidence: 99%

Unequal Efficacy of Pyridinium Oximes in Acute Organophosphate Poisoning

Antonijević¹,

Stojiljković²

2007

Clinical Medicine & Research

215

159

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“…Uses of organophosporus compounds (OPC) ranges from agriculture to warfield [2]. The mechanism of toxicity of OP compounds is the inhibition of acetylcholinesterase (AChE), resulting in an accumulation of acetylcholine and the continued stimulation of acetylcholine receptors.…”

Section: Discussionmentioning

confidence: 99%

Audiological Assessment in Organophosphorus Compound Poisoning

Murthy¹,

Reddy

2012

Indian J Otolaryngol Head Neck Surg

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The aim of this prospective study design is to understand the audiological parameters in central and peripheral auditory pathway in organophosphorus compound (OPC) poisoning, within the setting of Tertiary care/ Medical College Hospital we studied Distortion Product Oto Acoustic Emission (DPOAE) and brain evoked response audiometry (BERA) in 25 patients with OPC poisoning with respiratory failure and 75 patients without respiratory failure. The results showed that DPOAE was absent in 17 patients with respiratory failure and 51 patients without respiratory failure. BERA showed significant prolongation in wave I, wave III and wave V latencies in both the groups.In conclusion, the current study has demonstrated significant changes in the auditory pathway both in peripheral and central with OPC exposure. The damage induced by these agents has been suggested as a combination of oto-and neurotoxicity with or without respiratory failure. Otolaryngologist should be alert to the toxic properties of OPC and conduct a comprehensive audiological assessment even in the conditions of deliberate poisoning.

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Treatment of organophosphate poisoning. Experience of nerve agents and acute pesticide poisoning on the effects of oximes

Cited by 133 publications

References 4 publications

Study of clinical profile of organophosphorus poisoning with special reference to electrocardiographic changes and electrolyte derangement

Study of clinical profile of organophosphorus poisoning with special reference to electrocardiographic changes and electrolyte derangement

Unequal Efficacy of Pyridinium Oximes in Acute Organophosphate Poisoning

Audiological Assessment in Organophosphorus Compound Poisoning

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