Treatment of osteoarthritis with infrapatellar fat pad derived mesenchymal stem cells in Rabbit

Toghraie, Fatemeh Sadat; Chenari, Nooshafarin; Gholipour, Mohammad Ali; Faghih, Zahra; Torabinejad, Simin; Dehghani, S.; Ghaderi, Abbas

doi:10.1016/j.knee.2010.03.001

Cited by 145 publications

(133 citation statements)

References 24 publications

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“…Adult MSCs were first isolated from bone marrow (BM-MSCs) in 1999 by Pittenger et al [56], who demonstrated their multi-lineage differentiation potential, and have been extensively studied since then [56]. Adipose-derived MSCs (ADSCs) are typically harvested from the patients' adipose tissue through surgical resection or liposuction and infrapatellar fat pads (IFPs) that provide higher chondrogenic potential cells compared to other sources [34,57].…”

Section: Mscs Sourcesmentioning

confidence: 99%

Osteoarthritis and Mesenchymal Stem Cell Therapy: An Overview

Purwanthi¹,

Marta²,

Adiwardhana³

2017

Recent Advances in Biology and Medicine

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Osteoarthritis (OA) is the most common form of arthritis that affects cartilage joints and leads to disability. OA becomes the major public health problem, as it is the most leading cause of disability and morbidity worldwide. Treatment choices for OA can be classified into several categories such as non-pharmacologic, pharmacologic, surgical therapy, and cell-based therapy. There is no curative treatment for OA, while conventional treatments that are commonly used focus on alleviating the pain as the main symptom of the disease. Mesenchymal stem cells (MSCs) that can be found in several tissues of human body offer a new strategy for OA treatment owing to their ability to differentiate into chondrocytes. This article provides an overview about the basic concept of osteoarthritis as well as an insight about the MSCs therapy, including their basic characteristics, source, and transplantation strategies in the OA area.

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Section: Mscs Sourcesmentioning

confidence: 99%

Osteoarthritis and Mesenchymal Stem Cell Therapy: An Overview

Purwanthi¹,

Marta²,

Adiwardhana³

2017

Recent Advances in Biology and Medicine

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“…MSCs are non-hematopoietic cells that originate from several sources, although the bestcharacterized populations derive from bone marrow (BMMSCs). Besides BM-MSCs for cartilage repair cells have been isolated from various tissues such as synovium, periosteum, adipose tissue or synovial fluid [12,48,49]. Among these cell lines, synovium-derived MSCs (SMSCs) have been recently recognized as an appropriate cell type with chondrogenic potential and high proliferative capacity [49].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

“…The chondrogenic cells secrete many factors that stimulate MSC differentiation [11]. While several animal and clinical studies along these lines have been conducted, better understanding of the molecular events underlying the development of cartilaginous tissue is necessary [12].…”

Section: Introductionmentioning

confidence: 99%

The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration

Augustyniak

Trzeciak

Richter

et al. 2014

International Orthopaedics (SICOT)

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Purpose The use of stem cells in regenerative medicine offers hope to treat numerous orthopaedic disorders, including articular cartilage defects. Although much research has been carried out on chondrogenesis, this complicated process is still not well understood and much more research is needed. The present review provides an overview of the stages of chondrogenesis and describes the effects of various growth factors, which act during the multiple steps involved in stem celldirected differentiation towards chondrocytes. Methods The current literature on stem cell-directed chondrogenesis, in particular the role of members of the transforming growth factor-β (TGF-β) superfamily-TGF-βs, bone morphogenetic proteins (BMPs) and fibroblast growth factors (FGFs)-is reviewed and discussed. Results Numerous studies have reported the chondrogenic potential of both adult-and embryonic-like stem cells and the role of growth factors in programming differentiation of these cells towards chondrocytes. Mesenchymal stem cells (MSCs) are adult multipotent stem cells, whereas induced pluripotent stem cells (iPSC) are reprogrammed pluripotent cells. Although better understanding of the processes involved in the development of cartilage tissues is necessary, both cell types may be of value in the clinical treatment of cartilage injuries or osteoarthritic cartilage lesions. Conclusions MSCs and iPSCs both present unique characteristics. However, at present, it is still unclear which cell type is most suitable in the treatment of cartilage injuries.

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“…Toghraie et al [50], obtained MSCs for the IFP of rabbits and expanded the cells in vitro. The expanded MSCs were later injected into the knee joints of the rabbits 12 weeks after anterior cruciate ligament transection.…”

Section: Synovial Cellsmentioning

confidence: 99%

Chondrogenic Progenitor Cells and Articular Cartilage Repair

Chu

Friel²

2012

Rheumatology

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Treatment of articular cartilage injury is challenging due in part to the paucity of potential repair cells within articular cartilage. While chondrocytes can be expanded in culture and returned to the site of injury, autologous applications require removal of healthy articular cartilage -a limited resource. Additional sources of chondrogenic progenitor cells that may be suitable for articular cartilage repair include Mesenchymal Stem Cells (MSCs) isolated from more abundant tissues such as bone marrow, synovium, infrapatellar fat pad, subcutaneous fat, periosteum, perichondrium, and muscle.

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Treatment of osteoarthritis with infrapatellar fat pad derived mesenchymal stem cells in Rabbit

Cited by 145 publications

References 24 publications

Osteoarthritis and Mesenchymal Stem Cell Therapy: An Overview

Osteoarthritis and Mesenchymal Stem Cell Therapy: An Overview

The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration

Chondrogenic Progenitor Cells and Articular Cartilage Repair

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