Context
The effect of periodontal therapy on diabetes outcomes has not been established.
Objective
This update examines the effect of periodontal treatment on diabetes outcomes.
Data Sources
Literature since October 2009 using MEDLINE.
Study eligibility criteria
Published RCTs including periodontal therapy for diabetic subjects, a metabolic outcome, an untreated control group, and follow up of 3 months.
Data Extraction
Predefined data fields, including study quality indicators were used.
Data Synthesis
A search revealed 56 publications of which 9 met inclusion criteria. Mean change of HbA1c from baseline was compared across treatment groups. Pooled analysis was based on random effects models.
Results
A meta analysis indicated a mean treatment effect of −0.36% HbA1c (CI −0.54, − 0.19) compared to no treatment after periodontal therapy (p<0.0001). Heterogeneity tests revealed only minimal evidence of publication bias (I2 =9%).
Limitations
Small sample size and high risk of bias remain problematic for studies of this type. Periodontal therapy varied considerably.
Conclusion
The modest reduction in HbA1c observed as a result of periodontal therapy in subjects with type 2 diabetes is consistent with previous systematic reviews. Despite this finding, multi-center trials of sufficient sample size are lacking.