Treatment of Pernicious Anemia by Oral Administration of Vitamin B₁₂without Added Intrinsic Factor

Long-term Trial of Oral Treatment of Pernicious Anaemia with Vitamin-B12-Peptide

“…Previous reports on crystalline vitamin-B12 oral therapy (Reisner et al, 1955;Conley and Krevans, 1955;Brody et al, 1959;Thompson et al, 1962) show that doses ranging from 100 jig. daily to 1,000 jig.…”

Oral Treatment of Pernicious Anaemia with Vitamin-B12--Peptide

“…Clinical and haematological remissions have been maintained by giving orally 1,000-3,000 Ikg. every one to four weeks (Conley and Krevans, 1955;Reisner et al, 1955;Unglaub and Goldsmith, 1955) or 50-500 Mg. each day (Chalmers and Shinton, 1958;Brody et al, 1959;McIntyre et al, 1960). However, with doses less than 150 Mg. daily or 1,000 jug.…”

Oral Treatment of Pernicious Anaemia: First Fifty Cases

“…The effect of oral crystalline vitamin B12 in pernicious anaemia has been studied extensively, and most of the work on this subject has been reviewed by Ungley (1952), by Brody et al (1959), or by ourselves Mooney, 1958a, 1958b). The differing schemes of dosage employed in the studies make it difficult to summarize the findings in precise terms, but there appears to be fairly general agreement that dosages of at least 100 jug.…”